ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2010, Vol. 18 ›› Issue (9): 1458-1470.

• • 上一篇    下一篇

运动抗抑郁作用的神经营养假说

王泽军;季浏;褚昕宇   

  1. (1华东师范大学体育与健康学院, 上海 200241) (2上海工程技术大学体育部, 上海 201620)
  • 收稿日期:2010-04-09 修回日期:1900-01-01 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 季浏

The Neurotrophic Hypothesis of Antidepressant Actions of Exercise

WANG Ze-Jun;JI Liu;CHU Xin-Yu   

  1. (1College of Physical Education and Health, East China Normal University, Shanghai 200241, China)
    (2Department of Physical Education, Shanghai University of Engineering Science, Shanghai 201620, China)
  • Received:2010-04-09 Revised:1900-01-01 Online:2010-09-15 Published:2010-09-15
  • Contact: JI Liu

PDF (PC)

2123

被引次数

33

摘要： 身体锻炼具有促进心理健康的作用, 特别是通过体育锻炼能够有效缓解抑郁样症状及临床抑郁。有关抑郁的神经营养假说认为, 抑制成年海马神经发生以及神经营养因子的表达是导致抑郁的关键因素; 增加成年海马神经发生以及神经营养因子的表达能够产生抗抑郁的作用。本文通过综述认为, 运动能够诱导成年海马神经发生以及神经营养因子表达的增加可能是运动抗抑郁作用的主要机制, 且类似于药物的抗抑郁治疗作用。

关键词: 运动, 抑郁, 应激, 神经发生, 神经营养因子, 胞内信号传导, 基因转录

Abstract: Physical exercise has beneficial effects on mental health. In particular, exercise was shown to reduce depressive symptomatology and clinical depression. The neurotrophic hypothesis of depression believed that decreased neurogenesis in the adult hippocampus and expression of neurotrophic factors contributes to depression, but up-regulation of both neurogenesis in the adult hippocampus and expression of neurotrophic factors plays a key role in the actions of antidepressant treatment. Like antidepressants, chronic wheel-running exercise also increases neurotrophic factors expression and adult neurogenesis in the hippocampus. This review provides that exercise results in antidepressant-like behavioral changes that may involve a neurotrophic mechanism similar to that hypothesized for antidepressant treatments.

Key words: exercise, depression, stress, neurogenesis, neurotrophic factors, intracellular signaling transduction, gene transcription