ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2014, Vol. 22 ›› Issue (12): 1899-1910.doi: 10.3724/SP.J.1042.2014.01899

• 研究前沿 • 上一篇    下一篇

MAOA基因与抑郁的关系

曹丛;陈光辉;王美萍;曹衍淼;张文新   

  1. (山东师范大学心理学院, 济南 250014)
  • 收稿日期:2014-06-05 出版日期:2014-12-15 发布日期:2014-12-15
  • 通讯作者: 张文新, E-mail: wxzhang01@hotmail.com
  • 基金资助:

    国家自然科学基金项目(31271105)、高等学校博士学科点专项科研基金项目(20133704110001)、“十二五”强化建设重点学科(发展与教育心理学)建设经费资助项目。

Association between MAOA Gene and Depression

CAO Cong; CHEN Guanghui; WANG Meiping; CAO Yanmiao; ZHANG Wenxin   

  1. (School of Psychology, Shandong Normal University, Jinan 250014, China)
  • Received:2014-06-05 Online:2014-12-15 Published:2014-12-15
  • Contact: ZHANG Wenxin, E-mail: wxzhang01@hotmail.com

PDF (PC)

2325

被引次数

10

摘要：

抑郁的发生具有遗传基础。近年来, 随着分子遗传技术的发展, 对抑郁遗传机制的研究已经深入到分子水平。既有研究表明, MAOA基因在抑郁的发生发展中发挥着十分重要的作用。MAOA基因与抑郁间存在紧密的直接关联, 而且MAOA基因与环境及其他基因亦交互作用于抑郁, 然而, 既有相关研究结论尚存分歧。未来研究应更加关注MAOA基因与多种环境因素及其它基因间的复杂交互作用, 考察MAOA基因的年龄效应, 揭示MAOA基因作用于抑郁的脑机制。

关键词: MAOA基因, 抑郁, G×E交互作用, MAOA-uVNTR

Abstract:

The development of depression has important underpinnings. With the advancement of molecular genetics, the research on the mechanisms of depression has reached molecular level in recent years. Recent studies have demonstrated that the MAOA (monoamine oxidase A) gene has played an important role in depression. Evidence has been reported that MAOA gene had a direct effect on depression, and MAOA gene interacted with environments and other genes in predicting depression. However, the related research findings have not been always consistent and even contradictory in some cases. Future research should focus on such issues as the complex interactions between MAOA gene and multi-environments or other genes, examining the age effect of MAOA gene on depression, and its underlying neurobiological mechanisms.

Key words: MAOA gene, depression, gene-environment interaction, MAOA-uVNTR