ISSN 1671-3710
CN 11-4766/R

心理科学进展 ›› 2023, Vol. 31 ›› Issue (5): 783-799.doi: 10.3724/SP.J.1042.2023.00783

• 研究前沿 • 上一篇    下一篇


刘文华1,2(), 温秀娟1,2, 陈灵2, 杨瑞1,2, 胡逸儒1   

  1. 1广州医科大学附属脑科医院, 广州 510370
    2广州医科大学卫生管理学院, 广州 511436
  • 收稿日期:2022-08-23 出版日期:2023-05-15 发布日期:2023-02-13
  • 通讯作者: 刘文华

Reward-anticipation and outcome-evaluation ERPs and its application in psychiatric disorders

LIU Wenhua1,2(), WEN Xiujuan1,2, CHEN Ling2, YANG Rui1,2, HU Yiru1   

  1. 1The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510370, China
    2School of Health Management, Guangzhou Medical University, Guangzhou 511436, China
  • Received:2022-08-23 Online:2023-05-15 Published:2023-02-13
  • Contact: LIU Wenhua


临床上精神疾病如抑郁症、精神分裂症和双相情感障碍患者均表现出奖赏加工异常现象。奖赏加工包括多个产生时间非常接近的子过程。事件相关电位作为一种时间分辨率高且广泛使用的测量大脑皮层活动的工具, 非常适合于研究奖赏加工中复杂、多面的认知子结构。然而, 很多研究往往只关注测量单一脑电成分, 忽视对整体过程的探讨。奖赏加工可分为两个重要的子阶段并关联着多个相关的事件相关电位成分:奖励期待(线索N2和P3波, 关联性负变波和刺激前负波)和结果评估(反馈负波、反馈P3波和反馈晚期正电位), 这些脑电成分的异常活动与抑郁症、精神分裂症和双相情感障碍患者的临床症状有密切关联。采用多成分的脑电分析方法, 有助于更好地理解精神疾病群体在奖赏加工不同阶段的异常情况, 对促进疾病测评方式的发展也具有作用。

关键词: 奖励, 事件相关电位, 期待, 抑郁症


Reward processing abnormalities are prominent in the clinical presentation of patients with major depression, bipolar disorder and schizophrenia. Reward processing comprises a dynamic set of cognitive component processes that may occur temporally adjacent to each other. Event-related potentials (ERPs), as one of the most commonly used tools to assess cognitive processing with a high temporal resolution, is a useful method to investigate complex, multifaceted constructs composed of the substages of reward processing. However, ERP research in psychiatric conditions has typically focused on a single component of reward processing rather than capturing the dynamics of reward processing. Reward processing can be decomposed into two temporally distinct stages: reward-anticipation and outcome-evaluation, each of which is associated with different ERP components (i.e., reward-anticipation: cue-related N2 and P3, stimulus-preceding negativity or SPN and contingent-negative variation or CNV; outcome-evaluation: feedback-related negativity or FRN/reward positive or RewP, feedback-related P3 or FB-P3 and the late positive potential or FB-LPP), and abnormal activities of these ERPs are closely related to transdiagnostic psychiatric symptoms. Attenuated cue-related N2 (associated with conflict detection) and cue-related P3 (associated with attention allocation) during reward-anticipation stage and blunted FRN/RewP (an initial reactivity to receipt of feedback) and FB-LPP (a sustained processing of motivationally salient stimuli) during outcome-evaluation stage could be found in patients with major depression compared to healthy controls, suggesting a reduced reward sensitivity in patients with depression. For CNV (associated with motor preparation), SPN (associated with anticipation feedback), and FB-P3 (associated with the evaluation of feedback), no consistent findings emerge in previous depression studies. Patients with schizophrenia exhibit abnormal activities of cue-related N2, cue-related P3 and SPN during reward-anticipation stage, and evidences of abnormal ERPs activities are inconclusive during outcome-evaluation stage. Currently few studies have investigated the reward-related ERP components in patients with bipolar disorder. Preliminary findings suggest that patients with bipolar disorder might have enhanced FRN activities during different stages of disease development. Further research should carefully consider some factors which might have an influence on the results, such as small samples, different experimental paradigms and data analysis methods, and the disease state of patients. In conclusion, utilizing multistage experimental designs and implementing multicomponent analyses hold great promise to investigate neurophysiological abnormalities during different stages of reward processing in psychiatric disorders.

Key words: reward, ERP, anticipation, depression