ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2016, Vol. 24 ›› Issue (5): 725-738.doi: 10.3724/SP.J.1042.2016.00725

• 研究前沿 • 上一篇    下一篇

情绪通路异常与认知情绪偏差：慢性痛与抑郁症共病的神经心理机制

林潇骁1,2;罗 非1;王锦琰1   

  1. (1中国科学院心理研究所 心理健康院重点实验室, 北京 100101) (2中国科学院大学, 北京 100049)
  • 收稿日期:2015-05-16 出版日期:2016-05-15 发布日期:2016-05-15
  • 通讯作者: 罗非, E-mail: luof@psych.cn

Emotional circuit abnormalities and cognitive affective bias: Neuropsychological mechanisms of pain-depression comorbidity

LIN Xiaoxiao1,2; LUO Fei1; WANG Jingyan1   

  1. (1 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) (2 University of Chinese Academy of Sciences, Beijing 100049, China)
  • Received:2015-05-16 Online:2016-05-15 Published:2016-05-15
  • Contact: LUO Fei, E-mail: luof@psych.cn

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摘要：

慢性疼痛与抑郁症具有高度共病性, 但迄今尚无成熟理论能够阐释二者共病的神经心理机制。对慢性痛与抑郁的脑机制研究提示, 慢性痛和抑郁常常涉及到相似的情绪脑区活动的异常改变; 与此相对应的是, 行为学研究发现, 疼痛患者与抑郁患者在加工疼痛或抑郁相关信息时表现出了模式相似的认知情绪偏差(CAB)。近年来, 越来越多证据趋于一致, 指出慢性痛和抑郁共有的情绪通路异常变化可能导致了相似的信息加工异常, 是二者共病的神经心理基础, 而认知情绪偏差则在行为上反映了这种变化, 并且很可能是共病发生、发展及维持的重要因素。

关键词: 慢性痛, 抑郁症, 共病, 情绪通路, 认知情绪偏差

Abstract:

Comorbidity of chronic pain and depressive disorders are highly prevalent, yet no sound theory has been proposed to describe the underpinning neuropsychological mechanism. Brain imaging studies reveal that chronic pain and depressive disorders share similar emotional circuit abnormalities, which are in consistent with the fact that patients suffering from chronic pains or depression show similar cognitive- affective bias (CAB) towards pain-related or depression-related information in behavioral measures. Recently, convergent evidence strongly suggests that these emotional circuit abnormalities, causing similar deficits in information processing, may underlie the neuropsychological processes of pain-depression comorbidity. Cognitive-affective biases, as a set of behavioral indicators reflecting these abnormalities, may play an important role in emersion, development and maintenance of pain-depression comorbidity.

Key words: chronic pain, depression, comorbidity, emotional circuits, cognitive affective bias