ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

心理科学进展 ›› 2005, Vol. 13 ›› Issue (3): 327-332.

• • 上一篇    下一篇

焦虑和抑郁动物模型的研究方法和策略

亓晓丽,林文娟   

  1. 中国科学院心理研究所脑-行为研究中心,北京 100101
  • 收稿日期:2004-10-12 修回日期:1900-01-01 出版日期:2005-05-15 发布日期:2005-05-15
  • 通讯作者: 林文娟

Methods and Strategies of Anxiety and Depression Animal Models Study

Qi Xiaoli,Lin Wenjuan   

  1. Brain-Behavior Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
  • Received:2004-10-12 Revised:1900-01-01 Online:2005-05-15 Published:2005-05-15
  • Contact: Lin Wenjuan

摘要: 焦虑和抑郁障碍是严重威胁人们健康的精神疾病。焦虑和抑郁动物模型是通过一定的心理社会应激使动物产生明显的焦虑和抑郁情绪,模拟人类焦虑和抑郁障碍,以探讨其细胞、分子和基因水平机制。情绪障碍动物模型通常通过表面效度、结构效度和预测效度进行评价。目前的动物模型虽然存在一定的缺点,但已经为临床和科研提供了巨大帮助。

关键词: 心理社会应激, 焦虑, 抑郁, 动物模型

Abstract: Anxiety and depression disorders are severe mental diseases threatening humans’ health. Anxiety and depression animal models are applied to emulate humans’ anxiety and depression disorders on animals administrated psychosocial stress, So that their mechanism at cellular, molecular and genetic levels can be found out. Animal models are usually remarked by face validity, construct validity and predictive validity. Although there are some weakness in animal models now used , they have contributed much to the clinic and basic researches.

Key words: psychosocial stress, anxiety, depression, animal model.

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