ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 2009, Vol. 41 ›› Issue (11): 1054-1062.

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工作记忆的保持与操控:腹侧和背侧额叶皮层的特异性功能磁共振成像活动

Sara Pudas, Jonas Persson, L-G Nilsson & Lars Nyberg   

  1. (1 Department of Psychology, Stockholm University, 106 91 Stockholm, Sweden)
    (2 Departments of Integrative Medical Biology (Physiology) and Radiation Sciences (Diagnostic Radiology), Umeå University, 90187, Umeå, Sweden)
    (3Umeå Center for Functional Brain Imaging (UFBI); 4Stockholm Brain Institute)
  • 收稿日期:2009-09-11 修回日期:1900-01-01 出版日期:2009-11-30 发布日期:2009-11-30
  • 通讯作者: Sara Pudas

Maintenance and Manipulation in Working Memory: Differential Ventral and Dorsal Frontal Cortex fMRI Activity

Sara Pudas, Jonas Persson, L-G Nilsson & Lars Nyberg   

  1. (1 Department of Psychology, Stockholm University, 106 91 Stockholm, Sweden)
    (2 Departments of Integrative Medical Biology (Physiology) and Radiation Sciences (Diagnostic Radiology), Umeå University, 90187, Umeå, Sweden)
    (3Umeå Center for Functional Brain Imaging (UFBI); 4Stockholm Brain Institute)
  • Received:2009-09-11 Revised:1900-01-01 Online:2009-11-30 Published:2009-11-30
  • Contact: Sara Pudas

摘要: 为了进行大样本的老化与记忆的功能磁共振成像(fMRI)研究, 研究者设计了言语工作记忆的方案, 并且对一组健康青年人进行了施测。字母的呈现方式主要为两种条件: (i) 保持, 要求被试记住呈现的字母并且能够在4秒的间隔后保持; (ii) 操控, 被试需要将呈现的字母按字母表的顺序进行转换, 并且记住新的顺序。不管是用全脑分析, 还是用预先定义的感兴趣区域的分析方法, 对fMRI数据的分析表明本方案诱发了可靠的额叶皮层的激活, 且操控条件则引发了更为广泛的激活。背外侧和腹内侧前额叶的激活也表现出了不同特点, 操控引发了更多的背外侧前额叶激活。一些皮下区域也得到了激活, 特别是以前发现与工作记忆任务相关的一些区域。这说明该工作记忆研究方案适合探索额叶功能的与年龄相关的改变。

关键词: 额叶皮层, 功能磁共振成像, 工作记忆, 保持, 操控

Abstract: A verbal working memory protocol was designed and evaluated on a group of healthy younger adults in preparation for a large-scale functional magnetic resonance (fMRI) study on aging and memory. Letters were presented in two critical conditions: (i) maintenance, in which letters were to be memorized and kept in mind over a four second interval, and (ii) manipulation, in which letters were shifted forward in alphabetical order, and the new order was kept in mind. Analyses of fMRI data showed that the protocol elicited reliable activation in the frontal cortex, with manipulation producing more extensive activation patterns, both in whole-brain analyses and in predefined regions of interest (ROIs). There was also a distinction between dorsal and ventral lateral prefrontal regions, such that manipulation elicited more dorsolateral prefrontal activation. The protocol also elicited activation in various subcortical areas, previously associated with working-memory tasks. It was concluded that this working memory protocol is appropriate for investigating age-related changes in frontal-cortex functioning.

Key words: Frontal cortex, fMRI, working memory, maintenance, manipulation