ISSN 0439-755X
CN 11-1911/B
主办：中国心理学会
　　　中国科学院心理研究所
出版：科学出版社

心理学报 ›› 2000, Vol. 32 ›› Issue (3): 296-300.

• • 上一篇    下一篇

小剂量吗啡对大鼠活动性的影响

陈晶;胡家芬;董闽田;杨晓燕;隋南   

  1. 中国科学院心理研究所!北京100101,中国科学院心理研究所!北京100101,福建漳州175医院神经内科,中国科学院心理研究所!北京100101,中国科学院心理研究所!北京100101
  • 出版日期:2000-09-25 发布日期:2000-09-25
  • 通讯作者: 陈晶

THE EFFECTS OF LOW DOSE MORPHINE ON LOCOMOTOR ACTIVITIES IN RATS

Chen Jing ;Hu Jiafen; Deng Mintian ; Yang Xiaoyan; Sui Nan(Institute of Psychology, Chinese Academy of Sciences, Beijing 100101)   

  • Published:2000-09-25 Online:2000-09-25

摘要： 腹腔注射不同剂量吗啡（8，4，2，1mg／kg／day），观察各组大鼠在给药后不同时间内的活动性（locomotoractivity，LA）。连续给药8天，每天给药后95min内，每间隔15min，记录大鼠5min内在限定空间中所走格数。结果表明：随吗啡给药剂量或次数增加，LA呈升高趋势；使大鼠LA明显兴奋的适宜低剂量为4mg／kg／day，该剂量下每天给药后15－20minLA为峰值，而且此时段LA逐日升高，至第8日出现下降趋势。此结果在一定程度上动态地揭示了吗啡剂量、作用时间及其运动效应之间的相互关系。

关键词: 吗啡, 活动性, 剂量, 时间, 大鼠

Abstract: The locomotor achvities (LA) of rats were tested every 15 mins for 95 mins after morphine injected intraperitoneally with 8, 4, 2, 1mg/kg/day respectively once a day during the 8-day experiment,and the number of squares (10 X 10 cm2) which the rats passed by in 5 mins were recorded. Results showed that there were significant differences between the groups treared with 8 or 4mg/ kg / day of morphine and normal saline on day2-8, and between the groups with 2mg/kg/day of morphine and the control group on day2, 5 and 6. Thus 4mg / kg / day was the most suitable low dose of morphine for activating LA. The peak effect of 4mg/kg/day of morphine was at 15-20 mins after injection, and it kept going up for 8 days. It was suggested that low dose of morphine may be more stutable for related behavioral effects such as those of conditioned place preference or self-administration, and the best time course for training tasks may be within 20 min after the rats were exposed to morphine.

Key words: rats, low dose morphine, locomotor activity