Animal research paradigm and related neural mechanism of interval timing

doi:10.3724/SP.J.1042.2020.01478

Abstract

Abstract:

In exploring the brain mechanism of interval timing, animal research, compared with human subjects, can provide more evidence in pharmacology, molecular biology, single neuron electrophysiology and optogenetics. At present, the commonly used animal research paradigms of interval timing include temporal bisection task, peak-interval procedure and differential reinforcement of low rates. To be well fit for different research need, animal research paradigms are often adjusted. Animal research of interval timing were discussed from two aspects: (1) the introduction and comparison of the commonly used animal research paradigms of interval timing; (2) the research progress of neural mechanism of interval timing based on these paradigms, to provide a reference for further psychological research on time perception.

Key words: interval timing, animal research, experimental paradigm, neural mechanism, time perception/ temporal perception

CLC Number:

B845

WENG Chunchun, WANG Ning. Animal research paradigm and related neural mechanism of interval timing[J]. Advances in Psychological Science, 2020, 28(9): 1478-1492.

Figures/Tables 1

References 90

[1]	Asaoka, R., & Gyoba, J. (2016). Sounds modulate the perceived duration of visual stimuli via crossmodal integration. Multisensory Research, 29(4-5), 319-335. doi: 10.1163/22134808-00002518 URL pmid: 29384606
[2]	Azabou, E., Rohaut, B., Porcher, R., Heming, N., Kandelman, S., Allary, J., … the GENeR. (2018). Mismatch negativity to predict subsequent awakening in deeply sedated critically ill patients. British Journal of Anaesthesia, 121(6), 1290-1297. doi: 10.1016/j.bja.2018.06.029 URL pmid: 30442256
[3]	Bernardinis, M., Atashzar, S. F., Jog, M. S., & Patel, R. V. (2019). Differential temporal perception abilities in Parkinson's disease patients based on timing magnitude. Scientific Reports, 9(1), 19638. doi: 10.1038/s41598-019-55827-y URL pmid: 31873093
[4]	Blankenship, P. A., Cheatwood, J. L., & Wallace, D. G. (2017). Unilateral lesions of the dorsocentral striatum (DCS) disrupt spatial and temporal characteristics of food protection behavior. Brain Structure and Function, 222(6), 2697-2710. URL pmid: 28154968
[5]	Blomeley, F. J., Lowe, C. F., & Wearden, J. H. (2004). Reinforcer concentration effects on a fixed-interval schedule. Behavioural Processes, 67(1), 55-66. URL pmid: 15182926
[6]	Body, S., Cheung, T. H. C., Bezzina, G., Asgari, K., Fone, K. C. F., Glennon, J. C., … Szabadi, E. (2006). Effects of d-amphetamine and DOI (2, 5-dimethoxy-4-iodoamphetamine) on timing behavior: Interaction between D₁ and 5-HT_2A receptors. Psychopharmacology, 189(3), 331-343. URL pmid: 17051415
[7]	Body, S., Chiang, T. J., Mobini, S., Ho, M. Y., Bradshaw, C. M., & Szabadi, E. (2002). Effect of 8-OH-DPAT on temporal discrimination following central 5-hydroxytryptamine depletion. Pharmacology Biochemistry and Behavior, 71(4), 787-793. doi: 10.1016/S0091-3057(01)00674-8 URL
[8]	Body, S., Kheramin, S., Mobini, S., Ho, M. Y., Velazquez-Martinez, D. N., Bradshaw, C. M., & Szabadi, E. (2002). Antagonism by WAY-100635 of the effects of 8-OH-DPAT on performance on a free-operant timing schedule in intact and 5-HT-depleted rats. Behavioural Pharmacology, 13(8), 603-614. doi: 10.1097/00008877-200212000-00001 URL pmid: 12478210
[9]	Buhusi, C. V., & Meck, W. H. (2005). What makes us tick? Functional and neural mechanisms of interval timing. Nature Reviews Neuroscience, 6(10), 755-765. URL pmid: 16163383
[10]	Buhusi, C. V., & Meck, W. H. (2006). Time sharing in rats: A peak-interval procedure with gaps and distracters. Behavioural Processes, 71(2-3), 107-115. URL pmid: 16413701
[11]	Buhusi, C. V., & Meck, W. H. (2009). Relativity theory and time perception: Single or multiple clocks? Plos One, 4(7), e6268. doi: 10.1371/journal.pone.0006268 URL pmid: 19623247
[12]	Buonomano, D. V. (2000). Decoding temporal information: A model based on short-term synaptic plasticity. Journal of Neuroscience, 20(3), 1129-1141. URL pmid: 10648718
[13]	Cheng, R. K., MacDonald, C. J., & Meck, W. H. (2006). Differential effects of cocaine and ketamine on time estimation: Implications for neurobiological models of interval timing. Pharmacology Biochemistry and Behavior, 85(1), 114-122.
[14]	Cheng, R. K., Scott, A. C., Penney, T. B., Williams, C. L., & Meck, W. H. (2008). Prenatal-choline supplementation differentially modulates timing of auditory and visual stimuli in aged rats. Brain Research, 1237, 167-175. URL pmid: 18801344
[15]	Church, R. M., & Deluty, M. Z. (1977). Bisection of temporal intervals. Journal of Experimental Psychology-Animal Behavior Processes, 3(3), 216-228. URL pmid: 881613
[16]	Church, R. M., Meck, W. H., & Gibbon, J. (1994). Application of scalar timing theory to individual trials. Journal of Experimental Psychology-Animal Behavior Processes, 20(2), 135-155. URL pmid: 8189184
[17]	Coull, J. T., Cheng, R. K., & Meck, W. H. (2011). Neuroanatomical and neurochemical substrates of timing. Neuropsychopharmacology, 36(1), 3-25. doi: 10.1038/npp.2010.113 URL pmid: 20668434
[18]	Daniels, C. W., Watterson, E., Garcia, R., Mazur, G. J., Brackney, R. J., & Sanabria, F. (2015). Revisiting the effect of nicotine on interval timing. Behavioural Brain Research, 283, 238-250. URL pmid: 25637907
[19]	Deane, A. R., Millar, J., Bilkey, D. K., & Ward, R. D. (2017). Maternal immune activation in rats produces temporal perception impairments in adult offspring analogous to those observed in schizophrenia. Plos One, 12(11), e0187719. URL pmid: 29108010
[20]	de Corte, B. J., Wagner, L. M., Matell, M. S., & Narayanan, N. S. (2019). Striatal dopamine and the temporal control of behavior. Behavioural Brain Research, 356, 375-379.
[21]	Dews, P. B. (1978). Studies on responding under fixed-interval schedules of reinforcement: II. The scalloped pattern of the cumulative record. Journal of the Experimental Analysis of Behavior, 29(1), 67-75. URL pmid: 16812040
[22]	Doenyas, C., Mutluer, T., Genc, E., & Balcı, F. (2019). Error monitoring in decision-making and timing is disrupted in autism spectrum disorder. Autism Research, 12(2), 239-248. doi: 10.1002/aur.2041 URL pmid: 30485714
[23]	Droit-Volet, S. (2013). Time perception, emotions and mood disorders. Journal of Physiology-Paris, 107(4), 255-264.
[24]	Eckard, M. L., & Kyonka, E. G. E. (2018). Differential reinforcement of low rates differentially decreased timing precision. Behavioural Processes, 151, 111-118. URL pmid: 29608943
[25]	Eichenbaum, H. (2014). Time cells in the hippocampus: A new dimension for mapping memories. Nature Reviews Neuroscience, 15(11), 732-744. doi: 10.1038/nrn3827 URL pmid: 25269553
[26]	Faure, A., Es-Seddiqi, M., Brown, B. L., Nguyen, H. P., Riess, O., von Horsten, S., … Doyère, V. (2013). Modified impact of emotion on temporal discrimination in a transgenic rat model of Huntington disease. Frontiers in Behavioral Neuroscience, 7, 130. URL pmid: 24133419
[27]	Garces, D., El Massioui, N., Lamirault, C., Riess, O., Nguyen, H. P., Brown, B. L., & Doyère, V. (2018). The alteration of emotion regulation precedes the deficits in interval timing in the BACHD rat model for Huntington disease. Frontiers in Integrative Neuroscience, 12, 14. URL pmid: 29867384
[28]	Gibbon, J., Church, R. M., & Meck, W. H. (1984). Scalar timing in memory. Annals of the New York Academy Sciences, 423(1), 52-77.
[29]	Graham, S., Ho, M. Y., Bradshaw, C. M., & Szabadi, E. (1994). Facilitated acquisition of a temporal discrimination following destruction of the ascending 5-hydroxytryptaminergic pathways. Psychopharmacology, 116(3), 373-378. URL pmid: 7534424
[30]	Grommet, E. K., Hemmes, N. S., & Brown, B. L. (2019). The role of clock and memory processes in the timing of fear cues by humans in the temporal bisection task. Behavioural Processes, 164, 217-229. URL pmid: 31102605
[31]	Halberstadt, A. L., Sindhunata, I. S., Scheffers, K., Flynn, A. D., Sharp, R. F., Geyer, M. A., & Young, J. W. (2016). Effect of 5-HT_2A and 5-HT_2C receptors on temporal discrimination by mice. Neuropharmacology, 107, 364-375. doi: 10.1016/j.neuropharm.2016.03.038 URL pmid: 27020041
[32]	Hass, J., & Durstewitz, D. (2016). Time at the center, or time at the side? Assessing current models of time perception. Current Opinion in Behavioral Sciences, 8, 238-244.
[33]	Hata, T. (2011). Glutamate - A forgotten target for interval timing. Frontiers in Integrative Neuroscience, 5, 27. doi: 10.3389/fnint.2011.00027 URL pmid: 21734871
[34]	Herrnstein, R. J. (1964). Aperiodicity as a factor in choice. Journal of the Experimental Analysis of Behavior, 7(2), 179-182.
[35]	Hilgard, E. R. (1939). The behavior of organisms. Psychological Bulletin, 36(2), 121-125.
[36]	Höhn, S., Dallérac, G., Faure, A., Urbach, Y. K., Nguyen, H. P., Riess, O., … Doyère, V. (2011). Behavioral and in vivo electrophysiological evidence for presymptomatic alteration of prefrontostriatal processing in the transgenic rat model for huntington disease. Journal of Neuroscienc, 31(24), 8986-8997.
[37]	Ito, M. (1981). Control of monkey's spaced responding by sample durations. Japanese Psychological Research, 23(4), 213-218.
[38]	Jaldow, E. J., & Oakley, D. A. (1990). Performance on a differential reinforcement of low-rate schedule in neodecorticated rats and rats with hippocampal lesions. Psychobiology, 18(4), 394-403.
[39]	Jones, C. R., & Jahanshahi, M. (2009). The substantia nigra, the basal ganglia, dopamine and temporal processing. Journal of Neural Transmission Supplementa, (73), 161-171.
[40]	Jurek, L., Longuet, Y., Baltazar, M., Amestoy, A., Schmitt, V., Desmurget, M., & Geoffray, M. M. (2019). How did I get so late so soon? A review of time processing and management in autism. Behavioural Brain Research, 374, 112121. doi: 10.1016/j.bbr.2019.112121 URL pmid: 31376445
[41]	Kamada, T., & Hata, T. (2018). Insular cortex inactivation generalizes fear-induced underestimation of interval timing in a temporal bisection task. Behavioural Brain Research, 347, 219-226. URL pmid: 29551731
[42]	Kamada, T., & Hata, T. (2019). Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task. Behavioural Brain Research, 356, 227-235. URL pmid: 30098408
[43]	Kim, J., Ghim, J. W., Lee, J. H., & Jung, M. W. (2013). Neural correlates of interval timing in rodent prefrontal cortex. Journal of Neuroscience, 33(34), 13834-13847. URL pmid: 23966703
[44]	Kim, J., Jung, A. H., Byun, J., Jo, S., & Jung, M. W. (2009). Inactivation of medial prefrontal cortex impairs time interval discrimination in rats. Frontiers in Behavioral Neuroscience, 3, 38. URL pmid: 19915730
[45]	Kim, Y. C., Han, S. W., Alberico, S. L., Ruggiero, R. N., de Corte, B., Chen, K. H., & Narayanan, N. S. (2017). Optogenetic stimulation of frontal D1 neurons compensates for impaired temporal control of action in dopamine-depleted mice. Current Biology, 27(1), 39-47. URL pmid: 27989675
[46]	Kim, Y. C., & Narayanan, N. S. (2019). Prefrontal D1 dopamine-receptor neurons and delta resonance in interval timing. Cerebral Cortex, 29(5), 2051-2060. doi: 10.1093/cercor/bhy083 URL pmid: 29897417
[47]	Kleinman, M. R., Sohn, H., & Lee, D. (2016). A two-stage model of concurrent interval timing in monkeys. Journal of Neurophysiology, 116(3), 1068-1081. URL pmid: 27334954
[48]	Kurti, A. N., & Matell, M. S. (2011). Nucleus accumbens dopamine modulates response rate but not response timing in an interval timing task. Behavioral Neuroscience, 125(2), 215-225. URL pmid: 21463023
[49]	Lejeune, H., Ferrara, A., Soffie, M., Bronchart, M., & Wearden, J. H. (1998). Peak procedure performance in young adult and aged rats: Acquisition and adaptation to a changing temporal criterion. Quarterly Journal of Experimental Psychology Section B-Comparative and Physiological Psychology, 51(3), 193-217.
[50]	Lejeune, H., Wearden, J. H. (1991). The comparative psychology of fixed-interval responding: Some quantitative analyses. Learning and Motivation, 22(1-2), 84-111.
[51]	Leon, M. I., & Shadlen, M. N. (2003). Representation of time by neurons in the posterior parietal cortex of the macaque. Neuron, 38(2), 317-327. doi: 10.1016/s0896-6273(03)00185-5 URL pmid: 12718864
[52]	Lipponen, A., Kurkela, J. L. O., Kyläheiko, I., Hölttä, S., Ruusuvirta, T., Hämäläinen, J. A., & Astikainen, P. (2019). Auditory-evoked potentials to changes in sound duration in urethane-anaesthetized mice. European Journal of Neuroscience, 50(2), 1911-1919. URL pmid: 30687973
[53]	Liu, X. H., Wang, N., Wang, J. Y., & Luo, F. (2019). Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats. Scientific Reports, 9, 18683. doi: 10.1038/s41598-019-55168-w URL pmid: 31822729
[54]	Marinho, V., Oliveira, T., Bandeira, J., Pinto, G. R., Gomes, A., Lima, V., … Teixeira, S. (2018). Genetic influence alters the brain synchronism in perception and timing. Journal of Biomedical Science, 25(1), 61. doi: 10.1186/s12929-018-0463-z URL pmid: 30086746
[55]	Marshall, A. T., Smith, A. P., & Kirkpatrick, K. (2014). Mechanisms of impulsive choice: I. Individual differences in interval timing and reward processing. Journal of the Experimental Analysis of Behavior, 102(1), 86-101. URL pmid: 24965705
[56]	Matell, M. S., Kim, J. S., & Hartshorne, L. (2014). Timing in a variable interval procedure: Evidence for a memory singularity. Behavioural Processes, 101, 49-57. URL pmid: 24012783
[57]	Matell, M. S., & Meck, W. H. (2004). Cortico-striatal circuits and interval timing: Coincidence detection of oscillatory processes. Cognitive Brain Research, 21(2), 139-170. doi: 10.1016/j.cogbrainres.2004.06.012 URL pmid: 15464348
[58]	Matell, M. S., Meck, W. H., & Nicolelis, M. A. L. (2003). Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons. Behavioral Neuroscience, 117(4), 760-773. doi: 10.1037/0735-7044.117.4.760 URL pmid: 12931961
[59]	Meck, W. H. (1996). Neuropharmacology of timing and time perception. Cognitive Brain Research, 3(3-4), 227-242. doi: 10.1016/0926-6410(96)00009-2 URL pmid: 8806025
[60]	Meck, W. H. (2006). Neuroanatomical localization of an internal clock: A functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems. Brain Research, 1109(1), 93-107. doi: 10.1016/j.brainres.2006.06.031 URL pmid: 16890210
[61]	Meck, W. H., Cheng, R. K., MacDonald, C. J., Gainetdinov, R. R., Caron, M. G., & Cevik, M. Ö. (2012). Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice. Neuropharmacology, 62(3), 1221-1229.
[62]	Meck, W. H., & Church, R. M. (1987). Cholinergic modulation of the content of temporal memory. Behavioral Neuroscience, 101(4), 457-464. URL pmid: 2820435
[63]	Meck, W. H., Church, R. M., & Matell, M. S. (2013). Hippocampus, time, and memory-A retrospective analysis. Behavioral Neuroscience, 127(5), 642-654. URL pmid: 24128354
[64]	Meck, W. H., Penney, T. B., & Pouthas, V. (2008). Cortico-striatal representation of time in animals and humans. Current Opinion in Neurobiology, 18(2), 145-152. URL pmid: 18708142
[65]	Mello, G. B. M., Soares, S., & Paton, J. J. (2015). A scalable population code for time in the striatum. Current Biology, 25(9), 1113-1122. URL pmid: 25913405
[66]	Monterosso, J., & Ainslie, G. (1999). Beyond discounting: Possible experimental models of impulse control. Psychopharmacology, 146(4), 339-347. doi: 10.1007/pl00005480 URL pmid: 10550485
[67]	Näätänen, R., Paavilainen, P., Rinne, T., & Alho, K. (2007). The mismatch negativity (MMN) in basic research of central auditory processing: A review. Clinical Neurophysiology, 118(12), 2544-2590. doi: 10.1016/j.clinph.2007.04.026 URL pmid: 17931964
[68]	Nowak, K., Oron, A., Szymaszek, A., Leminen, M., Näätänen, R., & Szelag, E. (2016). Electrophysiological indicators of the age-related deterioration in the sensitivity to auditory duration deviance. Frontiers in Aging Neuroscience, 8, 2. URL pmid: 26834628
[69]	Oprisan, S. A., Aft, T., Buhusi, M., & Buhusi, C. V. (2018). Scalar timing in memory: A temporal map in the hippocampus. Journal of Theoretical Biology, 438, 133-142. URL pmid: 29155279
[70]	Orduña, V., García, A., Menez, M., Hong, E., & Bouzas, A. (2008). Performance of spontaneously hypertensive rats in a peak-interval procedure with gaps. Behavioural Brain Research, 191(1), 72-76. doi: 10.1016/j.bbr.2008.03.012 URL pmid: 18436313
[71]	Parker, K. L., Chen, K. H., Kingyon, J. R., Cavanagh, J. F., & Narayanan, N. S. (2014). D₁-dependent 4 Hz oscillations and ramping activity in rodent medial frontal cortex during interval timing. Journal of Neuroscience, 34(50), 16774-16783. doi: 10.1523/JNEUROSCI.2772-14.2014 URL pmid: 25505330
[72]	Parker, K. L., Ruggiero, R. N., & Narayanan, N. S. (2015). Infusion of D1 dopamine receptor agonist into medial frontal cortex disrupts neural correlates of interval timing. Frontiers in Behavioral Neuroscience, 9, 294. doi: 10.3389/fnbeh.2015.00294 URL pmid: 26617499
[73]	Rey, A. E., Michael, G. A., Dondas, C., Thar, M., Garcia-Larrea, L., & Mazza, S. (2017). Pain dilates time perception. Scientific Reports, 7(1), 15682. doi: 10.1038/s41598-017-15982-6 URL pmid: 29146989
[74]	Roberts, S. (1981). Isolation of an internal clock. Journal of Experimental Psychology: Animal Behavior Processes, 7(3), 242-268. URL pmid: 7252428
[75]	Roger, C., Hasbroucq, T., Rabat, A., Vidal, F., & Burle, B. (2009). Neurophysics of temporal discrimination in the rat: A mismatch negativity study. Psychophysiology, 46(5), 1028-1032. doi: 10.1111/j.1469-8986.2009.00840.x URL pmid: 19497011
[76]	Sidman, M. (1956). Time discrimination and behavioral interaction in a free operant situation. Journal of comparative and physiological psychology, 49(5), 469-473. doi: 10.1037/h0041892 URL pmid: 13376755
[77]	Smith, A. P., Marshall, A. T., & Kirkpatrick, K. (2015). Mechanisms of impulsive choice: II. Time-based interventions to improve self-control. Behavioural Processes, 112, 29-42. doi: 10.1016/j.beproc.2014.10.010 URL pmid: 25444771
[78]	Stubbs, A. (1968). The discrimination of stimulus duration by pigeons. Journal of the Experimental Analysis of Behavior, 11(3), 223-238. doi: 10.1901/jeab.1968.11-223 URL pmid: 5660703
[79]	Stubbs, D. A. (1980). Temporal discrimination and a free-operant psychophysical procedure. Journal of the Experimental Analysis of Behavior, 33(2), 167-185. URL pmid: 7365406
[80]	Sukhotina, I. A., Dravolina, O. A., Novitskaya, Y., Zvartau, E. E., Danysz, W., & Bespalov, A. Y. (2008). Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats. Psychopharmacology (Berl), 196(2), 211-220.
[81]	Sussman, E. S. (2007). A new view on the MMN and attention debate - The role of context in processing auditory events. Journal of Psychophysiology, 21(3-4), 164-175.
[82]	Swanton, D. N., Matell, M. S. (2011). Stimulus compounding in interval timing: The modality-duration relationship of the anchor durations results in qualitatively different response patterns to the compound cue Journal of Experimental Psychology-Animal Behavioral Processes, 37(1), 94-107.
[83]	Tam, S. K. E., Jennings, D. J., & Bonardi, C. (2013). Dorsal hippocampal involvement in conditioned-response timing and maintenance of temporal information in the absence of the CS. Experimental Brain Research, 227(4), 547-559. doi: 10.1007/s00221-013-3530-4 URL pmid: 23652722
[84]	Thönes, S., & Oberfeld, D. (2015). Time perception in depression: A meta-analysis. Journal of Affective Disorders, 175, 359-372. doi: 10.1016/j.jad.2014.12.057 URL pmid: 25665496
[85]	Toda, K., Lusk, N. A., Watson, G. D. R., Kim, N., Lu, D., Li, H. E., … Yin, H. H. (2017). Nigrotectal stimulation stops interval timing in mice. Current Biology, 27(24), 3763-3770. URL pmid: 29199075
[86]	Wallace, D. G., Wallace, P. S., Field, E., & Whishaw, I. Q. (2006). Pharmacological manipulations of food protection behavior in rats: Evidence for dopaminergic contributions to time perception during a natural behavior. Brain Research, 1112(1), 213-221. doi: 10.1016/j.brainres.2006.07.015 URL pmid: 16890923
[87]	Wilson, M. P., & Keller, F. S. (1953). On the selective reinforcement of spaced responses. Journal of Comparative and Physiological Psychology, 46(3), 190-193. doi: 10.1037/h0057705 URL pmid: 13061646
[88]	Wittmann, M. (2013). The inner sense of time: How the brain creates a representation of duration. Nature Reviews Neuroscience, 14(3), 217-223. doi: 10.1038/nrn3452 URL pmid: 23403747
[89]	Xu, M., Zhang, S. Y., Dan, Y., & Poo, M. M. (2014). Representation of interval timing by temporally scalable firing patterns in rat prefrontal cortex. Proceedings of the National Academy of Sciences, 111(1), 480-485.
[90]	Yamaguchi, K., & Sakurai, Y. (2014). Novel behavioral tasks to explore cerebellar temporal processing in milliseconds in rats. Behavioural Brain Research, 263, 138-143. URL pmid: 24487009

范式类别	重要参数	参数意义	优点	缺点
时间二分任务	主观相等点	时距知觉加工速度	更适用于考察时间敏感性	动物需要进行二分判断, 而不是直接估计时距
时间二分任务	韦伯分数	时间敏感性	更适用于考察时间敏感性	动物需要进行二分判断, 而不是直接估计时距
峰值间隔法	峰值时间	时距知觉加工速度	动物在操作过程中较为自由, 可以主观判断时距	动物反复按压杠杆, 在记录神经元时容易受到运动的影响
	峰值反应率	个体兴奋度
	韦伯分数	时间敏感性
低比率差别强化法	峰值时间	时距知觉加工速度	动物需要等待特定时长, 更接近人类研究的产生式法	容易受到个体冲动性的影响
低比率差别强化法	冲动反应数&未强化反应数	个体冲动性	动物需要等待特定时长, 更接近人类研究的产生式法	容易受到个体冲动性的影响
自由操作心理物理法	无差别点	时距知觉加工速度	行为操作快速, 适用于长时距研究	自由操作过程中易混杂其他因素
失匹配负波	波幅和潜伏期	对时距的辨别	不受注意限制, 可考察时距知觉的自动加工过程	观察的时间窗较小
录制观察法	某种行为的时长	时距知觉加工速度	可观察动物在自然状态下日常行为的时距知觉变化, 不受到训练因素的影响	可量化的日常行为目前仍然较少

范式类别	重要参数	参数意义	优点	缺点
时间二分任务	主观相等点	时距知觉加工速度	更适用于考察时间敏感性	动物需要进行二分判断, 而不是直接估计时距
时间二分任务	韦伯分数	时间敏感性	更适用于考察时间敏感性	动物需要进行二分判断, 而不是直接估计时距
峰值间隔法	峰值时间	时距知觉加工速度	动物在操作过程中较为自由, 可以主观判断时距	动物反复按压杠杆, 在记录神经元时容易受到运动的影响
	峰值反应率	个体兴奋度
	韦伯分数	时间敏感性
低比率差别强化法	峰值时间	时距知觉加工速度	动物需要等待特定时长, 更接近人类研究的产生式法	容易受到个体冲动性的影响
低比率差别强化法	冲动反应数&未强化反应数	个体冲动性	动物需要等待特定时长, 更接近人类研究的产生式法	容易受到个体冲动性的影响
自由操作心理物理法	无差别点	时距知觉加工速度	行为操作快速, 适用于长时距研究	自由操作过程中易混杂其他因素
失匹配负波	波幅和潜伏期	对时距的辨别	不受注意限制, 可考察时距知觉的自动加工过程	观察的时间窗较小
录制观察法	某种行为的时长	时距知觉加工速度	可观察动物在自然状态下日常行为的时距知觉变化, 不受到训练因素的影响	可量化的日常行为目前仍然较少