ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2016, Vol. 24 ›› Issue (12): 1864-1872.doi: 10.3724/SP.J.1042.2016.01864 cstr: 32111.14.2016.01864

• 研究前沿 • 上一篇    下一篇

发展性阅读障碍的脑区连接异常

冯小霞; 李 乐;丁国盛   

  1. (北京师范大学认知神经科学与学习国家重点实验室, 北京 100875)
  • 收稿日期:2016-06-02 出版日期:2016-12-15 发布日期:2016-12-15
  • 基金资助:

    国家自然科学基金(81171016, 31571158)资助。

Abnormal inter-regional brain connectivity in developmental dyslexia

FENG Xiaoxia; LI Le; DING Guosheng   

  1. (State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China)
  • Received:2016-06-02 Online:2016-12-15 Published:2016-12-15

PDF (PC)

2015

被引次数

3

摘要：

过去几十年中, 研究者基于脑区功能定位的思想对发展性阅读障碍的神经机制进行了大量的研究, 揭示出阅读障碍者在特定脑区的异常。近些年, 考虑到阅读加工过程的复杂性以及需要多脑区协同参与的特点, 越来越多的研究者从脑区连接的角度探讨阅读障碍的神经机制。结果发现阅读障碍者在阅读相关脑区间的白质结构连接和功能连接上均表现出异常, 这说明阅读技能受损和脑区连接异常之间存在着密切的联系。未来的研究还需进一步探讨脑区连接异常和特定脑区异常之间的关系, 以及结合基因、脑、行为和环境等多个因素探寻阅读障碍的发生机制。

关键词: 发展性阅读障碍, 神经机制, 结构连接, 任务态功能连接, 静息态功能连接

Abstract:

In the past decades, researchers have investigated the neural basis of developmental dyslexia and revealed the specific regional abnormality in dyslexics with a view of brain functional localization. However, given the complexity of reading process and its engagement of multiple regions, more and more researchers have studied this issue from an inter-regional brain connectivity perspective in recent years. These studies revealed that dyslexics exhibited disruption in both white matter structural connectivity and functional connectivity. These findings suggest a tight link between reading impairment and abnormalities in inter- regional brain connectivity. Future studies should explore the relationship between the connectivity disruption and specific regional abnormality in dyslexia and combine gene, brain, behavior, and environmental factors to investigate the pathogenetic mechanism of dyslexia.

Key words: developmental dyslexia, neural basis, structural connectivity, task-based functional connectivity, resting-state functional connectivity