心理科学进展 ›› 2024, Vol. 32 ›› Issue (7): 1138-1151.doi: 10.3724/SP.J.1042.2024.01138
曾庆贺, 崔晓宇, 唐为, 李娟
收稿日期:
2023-11-12
出版日期:
2024-07-15
发布日期:
2024-05-09
通讯作者:
李娟, E-mail: lijuan@psych.ac.cn
基金资助:
ZENG Qinghe, CUI Xiaoyu, TANG Wei, LI Juan
Received:
2023-11-12
Online:
2024-07-15
Published:
2024-05-09
摘要: 记忆辨别力是对相似的记忆经验进行准确辨别的能力, 其依赖于名为模式分离的神经计算机制, 在人类被试中, 通常使用记忆相似性任务对其进行测量与研究。在老化过程中, 老年人的记忆辨别力会出现十分明显的衰退, 这种衰退与海马、内嗅皮层等内侧颞叶脑区的结构和功能衰退以及其他新皮层结构和功能老化关系密切。由于记忆辨别力高度依赖于内侧颞叶的结构和功能完整性, 因此, 它能够反映出认知障碍发展早期的异常脑结构和功能变化, 使得记忆相似性任务具备了应用于认知障碍早期识别的巨大潜力。未来研究需要采用更精细的成像技术单独考察海马齿状回和CA3亚区在记忆辨别中的作用及其老化的影响, 并更多关注前额叶等新皮层结构老化影响记忆辨别力的神经机制, 同时也需要建立大样本前瞻队列来验证记忆相似性任务在认知障碍早期识别中的有效性。
中图分类号:
曾庆贺, 崔晓宇, 唐为, 李娟. (2024). 记忆辨别力受老化影响的认知神经机制及其应用. 心理科学进展 , 32(7), 1138-1151.
ZENG Qinghe, CUI Xiaoyu, TANG Wei, LI Juan. (2024). The cognitive neural mechanisms of age-related decline in mnemonic discrimination and its application. Advances in Psychological Science, 32(7), 1138-1151.
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