Abstract:  The existing studies have already shed light on the genetic underpinnings of antisocial behavior. MAOA gene is an important candidate gene of antisocial behavior. It has been demonstrated that the effect of MAOA gene on antisocial behavior is moderated by environment, however, its underlying mechanism remains unclear. The brain regions and neural circuits associated with emotional management, as well as related to working memory capacity might play an important role. Future research could focus on the issues of polygene-environment interaction, the validation of theoretical model on gene-environment interaction, and the possible mediating role of brain structure and functions.

Key words:  MAOA gene, antisocial behavior, gene-environment interaction, brain mechanism