Abstract:

There are three representative theory models about gene-environment interaction: diathesis-stress model, differential susceptibility model and vantage sensitivity model. Diathesis-stress model advocates that one who stays near ink gets stained black, vantage sensitivity model, however, suggests that one who stays near vermilion gets stained red, and differential susceptibility model is eclectic. To verify the above-mentioned model has been one of the focuses of research on gene-environment interaction. The grouping regression analysis and hierarchical regression analysis are the traditional methods to test these three models, and the region of significance and the re-parameterized regression model are the newly emerging ones. Future research could focus on the issues of domain-specificity, the ethnic difference, developmental change and the underlying mechanism of the gene-environment interaction. The measurement and method to examine the interaction between gene and environment also remain improved.

Key words: gene-environment interaction, diathesis-stress model, differential susceptibility model, vantage sensitivity model