ISSN 1671-3710
CN 11-4766/R

心理科学进展 ›› 2019, Vol. 27 ›› Issue (8): 1417-1426.doi: 10.3724/SP.J.1042.2019.01417

• 研究前沿 • 上一篇    下一篇


刘鹏1,2, 申鸿魁3   

  1. 1 山西师范大学教育科学学院心理系
    2 山西师范大学现代文理学院教育系
    3 山西师范大学网络信息中心, 临汾041004
  • 收稿日期:2018-07-03 出版日期:2019-07-26 发布日期:2019-06-25
  • 基金资助:
    *山西省应用基础研究计划面上青年项目(201801D 221391);山西省高等学校哲学社会科学研究项目(201803014);山西省教育科学“十三五”规划课题(GH-17028);2018年度山西师范大学现代文理学院基础研究重点项目(2018JCYJ13)

Modulating maladaptive human memory: Evidence from reconsolidation

LIU Peng1,2, SHEN Hongkui3   

  1. 1 Department of Psychology, Institute of Education Sciences, Shanxi Normal University, Linfen 041000, China
    2 Institute of Education, Modern College of Humanities and Sciences of Shanxi Normal University, Linfen 041000, China
    3 Shanxi Normal University Network Information Center, Linfen 041000, China
  • Received:2018-07-03 Online:2019-07-26 Published:2019-06-25


已经巩固的长时记忆被再次提取后, 进入一个记忆的不稳定期, 在此过程中, 记忆可被更新、强化、削弱甚至抹除, 这个过程称为再巩固。人类不良记忆再巩固研究揭示记忆激活后口服普萘洛尔(propranolol)或进行消退训练可削弱或抹除不良情绪记忆, 此过程中涉及杏仁核、海马、前额叶皮层等脑区的参与及其构成的神经环路的调控。当前临床上利用再巩固原理可通过药物治疗、行为干预或无创脑部刺激的方法改变不良记忆。然而, 由于其形成过程复杂并受多种因素影响, 未来研究应尽可能模拟临床中人类不良记忆形成的复杂环境, 深入探讨再巩固“边界问题”, 推动实验室研究向临床应用的转化。

关键词: 人类不良记忆, 再巩固, 临床干预, 边界条件


Stable memories may re-enter an unstable state when they are retrieved. Upon retrieval, a consolidated memory can be updated, strengthened, weakened, or even erased. This process is known as reconsolidation. Thus, reconsolidation interventions provide an opportunity to modify seemingly stable memories. Studies on the reconsolidation of maladaptive human memory emphasize the role of propranolol and behavioral intervention therapies in fear and episodic memory reconsolidation. Multiple cortical brain regions and neural circuits are involved in the reconsolidation of human fear and episodic memory. These include the amygdala, hippocampus, ventromedial prefrontal cortex (vmPFC), prefrontal cortex (PFC), the amygdale-vmPFC network, and the hippocampus-PFC network. Existing memories can be modified during reconsolidation by various interventions, such as drug treatment, behavioral therapy, or noninvasive brain stimulation. This introduces the possibility of using these strategies to treat memory disorders. However, there is a significant gap between the relevant basic research and the clinical application due to the complexity of pathologic memory formation. Therefore, additional experimental paradigms that more closely resemble clinical situations are required. Furthermore, the precise boundary conditions for reconsolidation disruption should be elucidated in a future study, as this will promote the clinical application of laboratory research.

Key words: maladaptive human memory, reconsolidation, clinical intervention, boundary conditions.