ISSN 1671-3710
CN 11-4766/R

心理科学进展 ›› 2020, Vol. 28 ›› Issue (2): 240-251.doi: 10.3724/SP.J.1042.2020.00240

• 研究前沿 • 上一篇    下一篇


陈伟1,2,3, 李俊娇4, 林小裔1, 张晓霞1, 郑希付1,2,3()   

  1. 1 华南师范大学心理学院
    2 华南师范大学心理应用研究中心, 广州 510631
    3 广东省心理健康与认知科学重点实验室, 广州 510631
    4 广东第二师范学院教师教育学院, 广州 510303
  • 收稿日期:2019-05-12 出版日期:2020-02-15 发布日期:2019-12-25
  • 通讯作者: 郑希付
  • 基金资助:
    * 国家自然科学基金项目(31771218);国家自然科学基金项目(31970996);华南师范大学研究生创新计划项目(2018WKXM004);幸福广州心理服务与辅导基地资助

Behavioral intervention of emotional memory reconsolidation: From bench to bedside

CHEN Wei1,2,3, LI Junjiao4, LING Xiaoyi1, ZHANG Xiaoxia1, ZHENG Xifu1,2,3()   

  1. 1 School of Psychology, South China Normal University, Guangzhou 510631, China
    2 Center for Studies of Psychological Application, South China Normal University, Guangzhou 510631, China
    3 Guangdong Key Laboratory of Mental Health and Cognitive Science, Guangzhou 510631, China
    4 College of Teacher Education, Guangdong University of Education, Guangzhou 510303, China
  • Received:2019-05-12 Online:2020-02-15 Published:2019-12-25
  • Contact: ZHENG Xifu


重新激活已经储存的记忆会重返暂时不稳定的状态, 需要经历重新稳定, 称为记忆再巩固。在这期间可以通过多种行为手段破坏、强化或更新原始记忆痕迹, 这为开发一种革命性的情绪记忆障碍治疗方法开辟了道路。然而, 即使在简单的实验模型中引发记忆再巩固的条件也是复杂的, 这给临床转化带来了困难与挑战。未来研究可以设置更具生态效应的基础模型, 寻求引发以及干预再巩固的最佳方式, 从神经生理、细胞分子层面进一步深化其内在机理研究。

关键词: 记忆再巩固, 行为干预, 情绪记忆, 转化科学


A consolidated memory trace can go back to an unstable state after reactivation and become susceptible to modulation, as long as it conforms to specific conditions. Memory reactivation serves as opening a short time window for the labile trace of memory be modified before coming into a new round of consolidation which is called the reconsolidation. It provides a transient opportunity to strengthen memories or disrupt undesired and maladaptive memories, so as to open avenues for developing a revolutionary treatment for emotional memory disorders. Behavioral intervention, however, is of especial significance in human studies as well as the clinical translation practice; and has been demonstrated as an effective way to interfere with destabilized memories. However, even in simple laboratory models, the conditions for inducing memory reconsolidation are complex, which highlights difficulties and challenges for clinical translation. We reviewed the main evidence and advances in the behavioral interference of memory reconsolidation, both in the laboratory and clinical practice. Future research can find its way to set up a more ecological experimental model to simulate the actual trauma and to build an optimal procedure to trigger and intervene memory reconsolidation. Additionally, the cooperation of studies of the neurophysiological, cellular and molecular levels is needed to deepen our understanding of the internal mechanism underlying the paradigm.

Key words: memory reconsolidation, behavioral intervention, emotional memory, translational science