ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

心理科学进展 ›› 2006, Vol. 14 ›› Issue (4): 522-531.

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成瘾药物心理依赖及复发的脑机制研究

郑希耕;李勇辉;隋南   

  1. 中国科学院心理研究所 心理健康重点实验室,北京 10010
  • 收稿日期:2006-05-28 修回日期:1900-01-01 出版日期:2006-07-15 发布日期:2006-07-15
  • 通讯作者: 隋南

The Brain Mechanisms of Psychological Dependence and Relapse of Abusive Drugs

Zheng Xigeng;Li Yonghui;Sui Nan   

  1. Institute of psychology, Chinese Academy of Sciences, Beijing 100101, China
  • Received:2006-05-28 Revised:1900-01-01 Online:2006-07-15 Published:2006-07-15
  • Contact: Sui Nan

摘要: 围绕学习、记忆、情绪及应激等心理因素与复发的关系,应用阿片类物质心理依赖研究条件性位置偏爱,条件性位置厌恶,Morris水迷宫量化觅药动机模型,行为及条件性行为敏感化等多种动物行为模型,从情绪相关学习、记忆在成瘾行为中的作用,不同神经核团与神经递质系统活动性的改变,应激相关因素易化的成瘾易感性,自然奖赏与成瘾药物奖赏相关记忆的比较研究等方面,对应激与记忆相关的吗啡心理依赖及复发的脑机制进行了系列研究

关键词: 学习记忆, 应激, 心理依赖, 成瘾易感性, 觅药动机, 自然奖赏

Abstract: This project focuses on investigations of the brain mechanisms of the psychological dependence of abusive drugs. By using various animal models, such as conditioned place preference (CPP), conditioned place aversion (CPA), drug-seeking intensity gradation model of Morris water maze, behavioral and conditioned behavioral sensitization, the roles of environmental stress, positive and negative emotional states on psychological dependence and its relapse, neural mechanism comparisons between drug reward and natural reward were explored from behavioral to neuronal and genetic level

Key words: Learning, Memory, Stress, Psychological dependence, Individual differences, Drug seeking, Natural reward

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