ISSN 1671-3710
CN 11-4766/R

心理科学进展 ›› 2021, Vol. 29 ›› Issue (2): 311-322.doi: 10.3724/SP.J.1042.2021.00311

• 研究前沿 • 上一篇    下一篇


薛冰, 王雪娇, 马宁, 高军()   

  1. 认知与人格教育部重点实验室, 重庆 400715
  • 收稿日期:2020-04-27 出版日期:2021-02-15 发布日期:2020-12-29
  • 通讯作者: 高军
  • 基金资助:

Effects of oxytocin on psychological resilience: The neurochemical mechanisms in the hippocampus

XUE Bing, WANG Xuejiao, MA Ning, GAO Jun()   

  1. Key Laboratory of Cognition and Personality, Ministry of Education, Chongqing 400715, China
  • Received:2020-04-27 Online:2021-02-15 Published:2020-12-29
  • Contact: GAO Jun


心理韧性指个体面对逆境、挫折或重大威胁等应激情境下的有效且灵活适应的能力, 促进机体恢复正常的生理和心理功能。研究表明海马是调控心理韧性的重要脑区, 且催产素可能通过作用于海马增强心理韧性。海马内部环路内嗅皮层-齿状回-CA3可能调节恐惧记忆的泛化和消退以增强心理韧性; 海马外部环路齿状回-杏仁核-伏隔核及海马-伏隔核环路调节情绪, 可能分别通过促进奖赏和带来厌恶进而增强或降低心理韧性。催产素作用于海马增强心理韧性的可能途径有:催产素促进海马神经发生, 降低海马腹侧成熟神经元对应激的敏感性, 提高海马“模式分离”功能, 降低应激记忆泛化; 催产素恢复海马谢弗侧枝-CA1突触长时程增强, 促进机体适应应激; 催产素降低海马糖皮质激素受体水平, 重新建立机体稳态。

关键词: 心理韧性, 应激, 应激适应, 催产素, 海马


Psychological resilience refers to the process of effective and flexible adaptation in the face of adversity, trauma, tragedy, threats, and other significant sources of stress. It helps the organism restore to a normal physiological and psychological status. Psychological resilience plays a major mediating role in the development of post-traumatic mental illness in individuals. It can predict the negative emotions after stress and determine the adaptation to stress. It has a significant influence on physical and mental health. Previous studies have shown that the hippocampus plays an important role in psychological resilience, and oxytocin may promote psychological resilience by modulating the hippocampus. However, the specific regulation mechanisms of them have not yet been systematically researched and elucidated. This review focuses on the role of oxytocin in the hippocampus on regulating psychological resilience and try to clarify the underlying mechanisms. It can help to further understand the mechanisms of psychological resilience and help to reduce the incidence of post-traumatic mental illness.
Hippocampus regulates psychological resilience through the internal and external projection circuits. On the internal circuit of the hippocampus, studies suggest that “entorhinal cortex-dentate gyrus-CA3” circus in the hippocampus may improve psychological resilience by reducing the generalization or promoting the extinction of stress-related memory. On the external circuit of the hippocampus, the “dentate gyrus-amygdala-nucleus accumbens” circuit and the “hippocampus-nucleus accumbens” circuit may enhance or reduce psychological resilience by promoting reward and disgust, respectively. There is a opposite effect on psychological resilience from the projection of the hippocampus to nucleus accumbens directly or indirectly. The basolateral amygdala may play a key role. Studies have shown that stress can cause complex interactions among basolateral amygdala, hippocampus and nucleus accumbens, so more research is necessary conducted to better understand its specific mechanisms. 
Oxytocin may regulate the hippocampus through four ways to improve psychological resilience. First, oxytocin promotes the neurogenesis of the hippocampus under stress by acting on the oxytocin receptor at the hippocampal CA3 pyramidal neurons. This can reduce the stress-induced harm. Second, oxytocin reduces the sensitivity of mature neurons in ventral hippocampus to stress by stimulating dentate gyrus neurogenesis. This can enhance the function of “pattern separation” in the dentate gyrus–CA3 circuit and reduce the generalization of stress-associated memory. Third, oxytocin increases the synaptic cell signaling pathway kinase levels on the CA3-CA1 pathway and promotes the ability of adaptation to stress by rescuing stress-induced impairments in NMDA receptor-dependent long-term potentiation of hippocampal Schaffer collateral-CA1 synapses. At last, oxytocin interacts with glucocorticoids and catecholamine systems to increase oxytocin release. The oxytocin release can inhibit the function of the hypothalamic–pituitary–adrenal axis and reduce hippocampal glucocorticoid receptor levels. This protects the structure and function of the hippocampus from glucocorticoid damage and re-establishes brain homeostasis. So, oxytocin can further adjust the stress-related memory and enhance psychological resilience.
At the same time, research suggests that oxytocin regulates psychological resilience by affecting the structure and function of the hippocampus, which might differ among individuals of different genders or experiences. In terms of individual diagnosis and treatment, it is necessary to combine these factors for reasonable treatment. Besides, the interaction between genes and the environment is also needed to be considered. To improve psychological resilience in a targeted manner, individual characteristics, interpersonal relationships, and emotional support needs to be considered in the treatment of stress-related mental illness. Finally, exploring the neural mechanisms of psychological resilience should be closely integrated with human research and animal research to make up for the deficiencies of each research. Future research should combine various technologies such as human brain imaging and animal neural circuits technologies to determine the fine brain structures and circuits that regulate psychological resilience.

Key words: psychological resilience, stress, stress adaptation, oxytocin, hippocampus