ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2011, Vol. 19 ›› Issue (8): 1174-1178.

• 研究前沿 • 上一篇    下一篇

应激神经成像的研究述评

杨娟;侯燕;张庆林   

  1. 西南大学心理学院; 认知与人格教育部重点实验室(西南大学), 重庆 400715
  • 收稿日期:2010-04-16 修回日期:1900-01-01 出版日期:2011-08-15 发布日期:2011-08-15
  • 通讯作者: 杨娟

A Commentary of Neuroendocrine Stress Response in the Functional Neuroimaging Context

YANG Juan;HOU Yan;ZHANG Qing-Lin   

  1. (School of Psychology, Southwest University; Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing 400715, China)
  • Received:2010-04-16 Revised:1900-01-01 Online:2011-08-15 Published:2011-08-15
  • Contact: YANG Juan

PDF (PC)

1911

被引次数

9

摘要： HPA轴(hypothalamic-pituitary-adrenal cortex axis)是人体的重要内分泌应激系统, 大脑通过控制HPA轴活动影响机体在应激情境中皮质醇(cortisol)的分泌, 同时皮质醇分泌对大脑也具有负反馈作用, 影响着大脑边缘系统的重塑; 海马、杏仁核、前额叶皮层和脑干都参与了应激反应中的皮质醇调节; 未来研究要进一步对应激源细化分类, 并且试图找到适合事件相关电位技术的社会心理性应激实验范式。

关键词: 应激, HPA轴, 皮质醇, 神经成像

Abstract: The hypothalamic-pituitary-adrenal (HPA) axis is the major endocrine stress axis of the human organism. Brain networks exercises their regulatory function on HPA axis function and cortisol regulation. Moreover, cortisol regulates its own release via the negative feedback loop in the central nervous system, where it influence stress responsiveness and alter the rate of brain and body aging. Hippocampus, amygdale, prefrontal cortex, and brainstem are involved in cortisol regulation in response to stress. Future study should classify different type of stressors and try to find experimental paradigms of psychosocial stress in the event-related potential (ERP) context.

Key words: stress, hypothalamic-pituitary-adrenal (HPA) axis, cortisol, neuroimaging