ISSN 1671-3710
CN 11-4766/R

心理科学进展 ›› 2022, Vol. 30 ›› Issue (8): 1856-1869.doi: 10.3724/SP.J.1042.2022.01856

• 研究前沿 • 上一篇    下一篇


周振友1, 孔丽1,2(), 陈楚侨3()   

  1. 1上海师范大学心理系, 上海 200234
    2华东师范大学城市化生态过程与生态恢复重点实验室, 上海 200241
    3中国科学院心理研究所心理健康重点实验室, 神经心理学与认知神经科学研究室, 北京 100101
  • 收稿日期:2021-10-09 出版日期:2022-08-15 发布日期:2022-06-23
  • 通讯作者: 孔丽,陈楚侨;
  • 基金资助:

The relationship between gut microbiota and brain imaging and clinical manifestation in schizophrenia

ZHOU Zhenyou1, KONG Li1,2(), CHAN Raymond3()   

  1. 1Department of Psychology, Shanghai Normal University, Shanghai 200234, China
    2Shanghai Key Lab for Urban Ecological Processes and Eco-restoration, East China Normal University, Shanghai 200241, China
    3Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
  • Received:2021-10-09 Online:2022-08-15 Published:2022-06-23
  • Contact: KONG Li,CHAN Raymond;


微生物-肠-脑轴假设在精神分裂症发病机制中的研究受到越来越多的关注。以往研究初步考察了肠道微生物的构成与精神分裂症患者脑影像和临床表征之间的联系, 但具体的作用路径尚不明确。当前研究通过总结最新研究进展, 并在此基础上提出肠道微生物影响精神分裂症患者大脑结构和功能的机制假设。相关内容对于进一步阐明精神分裂症的病理机制, 为将肠道微生物纳入精神分裂症的评估与干预提供理论基础。

关键词: 精神分裂症, 肠道微生物, 微生物-肠-脑轴, 脑影像, 临床表征


The microbiota-gut-brain axis hypothesis has attracted more and more attention in the research of the pathogenesis of schizophrenia. This hypothesis stated that gut microbiota can cause inflammation in the brain of patients with schizophrenia and cause abnormalities of brain function through the intestinal immune system, and that early colonization of gut microbiota will affect the development of the central nervous system in patients with schizophrenia and thus cause abnormalities of brain structure. Previous research has preliminarily investigated the relationship between the composition of gut microbiota and the brain imaging and clinical manifestation of patients with schizophrenia, but the specific action path is still unclear.

In the current research, we have summarized the latest research progress and found that the gut microbiota diversity of patients with schizophrenia is significantly lower than that of the normal control, and the relative abundance of gut microbiota is also significantly different from that of the normal control at different biological levels, which is mainly manifested as the increase in the relative abundance of Actinomycetes and Proteus as well as the decrease in the relative abundance of Bacteroides and Sclerotinia. Based on the brain imaging results of patients with schizophrenia, we found that there was a significant correlation between the diversity of gut microbiota and the relative abundance of certain microbiota and the gray volume of specific areas of the patient's brain, including the right middle frontal gyrus, the right postcentral gyrus and insula, as well as the Amplitude of Low Frequency Fluctuation index (ALFF) and Regional Homogeneity index (ReHo) in certain brain functional areas, which were mainly reflected in the functional signals of the frontal and temporal lobes. Further combined with the clinical manifestation analysis of patients with schizophrenia, the results showed that there was a significant correlation between the composition of gut microbiota and the cognitive function scores as well as the clinical symptom score (PANSS). The α diversity of gut microbiota was related to visual hallucination, and the relative abundance of Sclerotinia sclerotiorum was significantly and positively correlated with the negative symptom score.

These evidences indicate that the potential role of gut microbiota in schizophrenia is related to the changes of brain structure and function. Based on the ability of gut microbiota to identify and produce chemicals and the evidence of severe neurotransmitter imbalance in patients with schizophrenia, we proposed the mechanism hypothesis of gut microbiota affecting the brain structure and function of patients with schizophrenia, believing that gut microbiota may affect the brain structure and function of patients with schizophrenia through immune mediated pathway, short-chain fatty acid pathway, kynurenine pathway and brain-derived neurotrophic factor pathway. The related contents will provide new insights for further elucidation of the pathological mechanism of schizophrenia, clarify how gut microbiota affect the potential pathophysiological process of schizophrenia through the microbiota-gut-brain axis, and provide a theoretical basis for the inclusion of gut microbiota in the diagnosis, evaluation and intervention of schizophrenia.

Key words: schizophrenia, gut microbiota, microbiota-gut-brain axis, brain imaging, clinical manifestation