多巴胺D2受体参与调节感觉门控的机制

doi:10.3724/SP.J.1042.2021.01030

摘要/Abstract

摘要：

精神分裂症是一种常见的病因不明的精神疾病。大量文献表明精神分裂症患者所表现出来的认知紊乱和思维异常等症状与感觉门控功能的缺失有密切的关系, 感觉门控是指在充满刺激的环境中, 从外界的感觉信息中过滤无关的感觉信息然后执行与注意力相关的认知过程, 以对显著的刺激做出反应。研究感觉门控的经典范式是震惊反射的前脉冲抑制。研究发现多巴胺D₂受体可以参与调控前脉冲抑制的过程, 但是多巴胺D₂受体参与调控前脉冲抑制的机制仍不清楚。探讨多巴胺D₂受体参与调控感觉门控即前脉冲抑制的关键脑区、神经环路及分子机制, 有利于促进对精神分裂症感觉门控功能的深入研究。

关键词: 多巴胺, 感觉门控, 多巴胺D₂受体, 前脉冲抑制, 精神分裂症

Abstract:

Schizophrenia is a common psychotic disease whose etiology and mechanism are not well defined. It has been shown that the symptoms of cognitive disorder and abnormal thoughts of schizophrenics are associated with the deficit of sensory gating. Sensory gating refers to filter irrelevant sensory information from the external ones and then implement the cognitive process related to attention, so as to respond to prominent stimuli. The pre-pulse inhibition (PPI) paradigm is always used to study sensory gating. It has been found that dopamine D₂ receptors play a critical role in regulating PPI, but the mechanisms underlying the role of dopamine D₂ receptors in regulating PPI remain largely elusive. The review focuses on molecular mechanisms underlying the regulating effect of dopamine D2 receptors on sensory gating, so as to promote the in-depth study of sensory gating function in schizophrenia.

Key words: dopamine, sensory gating, dopamine D₂ receptor, pre-pulse inhibition, schizophrenia

中图分类号:

B845

欧华星, 陈伟海. (2021). 多巴胺D₂受体参与调节感觉门控的机制. 心理科学进展 , 29(6), 1030-1041.

OU Huaxing, CHEN Weihai. (2021). Mechanisms underlying the role of D₂ receptors in regulating sensory gating. Advances in Psychological Science, 29(6), 1030-1041.

图/表 2

图1 前脉冲抑制的初级环路。听觉传入到下丘, 上丘接收到下丘声音刺激的传入并将其传递到脑桥脚被盖核, 脑桥脚被盖核发出神经纤维, 投射到震惊反射中枢的尾侧脑桥网状核并发挥对震惊反射抑制性的调节作用。

图2 中脑边缘皮质-纹状体-腹侧苍白球-脑桥回路(CSPP)回路。腹侧被盖区向边缘皮质(前额叶、杏仁核、海马)发出多巴胺能神经纤维, 而纹状体接受来自边缘皮质的谷氨酸能神经投射和腹侧被盖区的多巴胺能神经投射, 并发出GABA能神经投射到腹侧苍白球、脑桥脚被盖核以及腹侧被盖区, 从而实现对PPI的调控。

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多巴胺D₂受体参与调节感觉门控的机制

Mechanisms underlying the role of D₂ receptors in regulating sensory gating

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