ISSN 1671-3710
CN 11-4766/R

心理科学进展 ›› 2018, Vol. 26 ›› Issue (11): 1992-2002.doi: 10.3724/SP.J.1042.2018.01992

• 研究前沿 • 上一篇    下一篇


邓潇斐1,2, 郭建友1()   

  1. 1 中国科学院心理研究所 心理健康院重点实验室, 北京 100101
    2 中国科学院大学, 北京 100049
  • 收稿日期:2017-12-04 出版日期:2018-11-15 发布日期:2018-09-26
  • 通讯作者: 郭建友
  • 基金资助:
    * 国家自然科学基金资助(30800301);* 国家自然科学基金资助(31170992);* 国家自然科学基金资助(31371038)

Roles of impaired parvalbumin positive interneurons in schizophrenic pathology

DENG Xiaofei1,2, GUO Jianyou1()   

  1. 1 Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
    2 University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2017-12-04 Online:2018-11-15 Published:2018-09-26
  • Contact: GUO Jianyou


精神分裂症是一种多发于青壮年的重性精神病, 其原因尚不明确。经典的多巴胺缺陷理论假说在某些方面欠缺解释力; 与此同时, 关于Parvalbumin阳性的中间神经元(后简称PV+神经元)缺陷在精神分裂症病理机制中的作用逐渐明晰, 并引起了越来越多的关注。PV+神经元在绝大部分脑区中是一种快速放电的抑制性神经元, 参与了突触可塑性的调节, 兴奋/抑制平衡的维持和神经发生等。而在精神分裂症中, PV+神经元的异常在患者和动物研究中都被普遍证实, 并发现与 NMDA受体缺陷、gamma波异常和氧化应激存在某些关联。

关键词: 精神分裂症, 中间神经元, NMDA受体, 氧化应激


Schizophrenia is a severe mental disorder typically began in late adolescence or early adulthood. To date, the cause of schizophrenia remains largely unclear. The classical dopamine hypothesis of schizophrenia is now thought to be sided. Meanwhile, the involvement of impaired Parvalbumin positive interneurons (PV+ neurons) in the pathological mechanism of schizophrenia has been realized and received increasing attention. Generally, PV+ cells is a kind of inhibitory, fast-spiking interneurons, which had been demonstrated to be involved in synaptic plasticity, excitation/inhibition balance and neurogenesis. In schizophrenia, abnormal PV+ neurons has been commonly found in patients and relevant animal models., In this article, we reviewed the roles of deficits of PV+ neurons in schizophrenic pathology combined its principal phenotypes including defective NMDA receptors, abnormal gamma oscillation and oxidative stress, hoping to contribute to further investigation and development of new drugs.

Key words: schizophrenia, interneurons, NMDA receptors, oxidative stress