主观记忆减退老年人情节记忆的行为表现及其脑机制

doi:10.3724/SP.J.1042.2019.00051

摘要/Abstract

摘要：

情节记忆是个体对特定时间,特定地点所经历的特定事件的记忆.主观报告情节记忆下降是主观记忆减退老年人最典型的表现.与健康对照组老年人相比, 主观记忆减退老年人情节记忆下降的速率更快, 罹患老年性痴呆的风险更高, 但其情节记忆加工的脑机制尚不明确.前人研究提示, 主观记忆减退老年人在外在记忆行为尚未出现损伤的情况下, 其大脑情节记忆相关脑区的神经活动已经出现异常.探究主观记忆减退的记忆神经环路关键节点和路径的异常, 揭示神经环路在老年痴呆发生发展中的变化规律, 对深入理解老年痴呆的发病机制有重要的科学意义.同时, 主观记忆减退老年人作为特殊的记忆损伤群体, 对其神经环路的深入探究, 也必将为揭示人类记忆的神经机制做出独特的贡献.

关键词: 情节记忆, 主观记忆减退, 老年性痴呆, 脑机制, 老年人

Abstract:

Episodic memory (EM) is the collection of past personal experiences that have occurred at a particular time and place. Subjective decline in EM is reported in the elderly with subjective memory decline (SMD). The elderly with SMD have a faster rate of EM decline and a higher risk of developing Alzheimer's disease (AD) than do healthy controls. However, the brain mechanisms of episodic memory impairment in SMD are unclear. Previous studies suggest that even when memory performance has no observable deficits, the brain structure and function associated with EM have been abnormal in SMD. Two further studies are of vital scientific significance for understanding the pathogenesis of AD. One is to explore the abnormal key nodes and paths of memory neural circuits in SMD. The other is to reveal the changes in the neural circuits in the progression of AD. In addition, considering that the elderly with SMD are a special group with memory impairment, an in-depth investigation into the neural circuits in this group, will make a unique contribution to revealing the neural mechanism of human memory.

Key words: episodic memory, subjective memory decline, Alzheimer's disease, brain mechanisms, elderly

中图分类号:

B844

尹述飞, 李添, 朱心怡. (2019). 主观记忆减退老年人情节记忆的行为表现及其脑机制. 心理科学进展 , 27(1), 51-59.

YIN Shufei, LI Tian, ZHU Xinyi. (2019). Episodic memory performance and underlying brain mechanisms in elderly with subjective memory decline. Advances in Psychological Science, 27(1), 51-59.

参考文献 76

1	韩璎, 左西年, 李会杰, 李淑宇, 卢洁, 夏明睿 , , et al. 王晓妮. (2015). 主观认知下降多模态脑影像研究进展. 医学研究杂志,44(6), 1-2. doi: 10.11969/j.issn.1673-548X.2015.06.001 URL
2	尹述飞, 朱心怡, 李娟 . (2016). 主观记忆减退老年人认知功能的可塑性(综述). 中国心理卫生杂志,30(8), 600-606. doi: 10.3969/j.issn.1000-6729.2016.08.008 URL
3	Amariglio R. E., Becker J. A., Carmasin J., Wadsworth L. P., Lorius N., Sullivan C ., et al. Rentz, D. M. (2012). Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia, 50(12), 2880-2886. doi: 10.1016/j.neuropsychologia.2012.08.011 URL pmid: 22940426
4	Amariglio R. E., Mormino E. C., Pietras A. C., Marshall G. A., Vannini P., Johnson K. A ., et al. Rentz, D. M. (2015). Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly. Neurology, 85(1), 56-62.
5	Amariglio R. E., Townsend M. K., Grodstein F., Sperling R. A., & Rentz D. M . (2011). Specific subjective memory complaints in older persons may indicate poor cognitive function. Journal of the American Geriatrics Society, 59(9), 1612-1617. doi: 10.1111/j.1532-5415.2011.03543.x URL pmid: 3315361
6	Bai F., Zhang Z. J., Watson D. R., Yu H., Shi Y. M., Yuan Y. G ., et al. Qian, Y. (2009). Abnormal functional connectivity of hippocampus during episodic memory retrieval processing network in amnestic mild cognitive impairment. Biological Psychiatry, 65(11), 951-958. doi: 10.1016/j.biopsych.2008.10.017 URL pmid: 19028382
7	Boa S. S. N., Gill D. P., Owen A. M., Liu-ambrose T., Hachinski V., Shigematsu R., & Petrella R. J . (2018). Cognitive changes following multiple-modality exercise and mind-motor training in older adults with subjective cognitive complaints: The M4 study. Plos One, 13(4), e0196356. doi: 10.1371/journal.pone.0196356 URL pmid: 29698440
8	Buckley R. F., Hanseeuw B., Schultz A. P., Vannini P., Aghjayan S. L., Properzi M. J ., et al. Amariglio, R. E. (2017). Region-specific association of subjective cognitive decline with tauopathy independent of global β-amyloid burden. Jama Neurology, 74(12), 1455-1463. doi: 10.1001/jamaneurol.2017.2216 URL pmid: 28973551
9	Buckley R. F., Maruff P., Ames D., Bourgeat P., Martins R. N., Masters C. L ., et al. Study, A. (2016). Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease. Alzheimer’s & Dementia, 12(7), 796-804. doi: 10.1016/j.jalz.2015.12.013 URL pmid: 26852195
10	Burns A., & Iliffe S. (2009). Alzheimer's disease. British Medical Journal, 338(7692), 158.
11	Carrasco P. M., Montenegro-Peña M., López-Higes R., Estrada E., Crespo D. P., & Rubio C. M ., et al. Azorín, D. G. (2017). Subjective memory complaints in healthy older adults: Fewer complaints associated with depression and perceived health, more complaints also associated with lower memory performance. Archives of Gerontology and Geriatrics, 70, 28-37. doi: 10.1016/j.archger.2016.12.007 URL pmid: 28039781
12	Cohen-Mansfield J., Cohen R., Buettner L., Eyal N., Jakobovits H., Rebok G ., et al. Sternberg, S. (2015). Interventions for older persons reporting memory difficulties: A randomized controlled pilot study. International Journal of Geriatric Psychiatry, 30(5), 478-486. doi: 10.1002/gps.4164 URL pmid: 25043482
13	Colijn M.A., &Grossberg G.T . (2015). Amyloid and tau biomarkers in subjective cognitive impairment. Journal of Alzheimer’s Disease, 47(1), 1-8. doi: 10.3233/JAD-150180 URL
14	Contreras J. A., Goñi J., Risacher S. L., Amico E., Yoder K., Dzemidzic M ., et al. Saykin, A. J. (2017). Cognitive complaints in older adults at risk for Alzheimer's disease are associated with altered resting-state networks. Alzheimers & Dementia: Diagnosis, Assessment & Disease Monitoring, 6, 40-49. doi: 10.1016/j.jalz.2016.06.073 URL pmid: 5266473
15	Cosentino S., Devanand D., & Gurland B . (2018). A link between subjective perceptions of memory and physical function: Implications for subjective cognitive decline. Journal of Alzheimer’s Disease, 61(4), 1387-1398. doi: 10.3233/JAD-170495 URL pmid: 29376850
16	Eichenbaum H., & Fortin N. (2003). Episodic memory and the hippocampus. Current Directions in Psychological Science, 12(2), 53-57. doi: 10.1002/9780470479216.corpsy0316 URL
17	Engvig A., Fjell A. M., Westlye L. T., Skaane N. V., Dale A. M., Holland D ., et al. Kristine, W. (2014). Effects of cognitive training on gray matter volumes in memory clinic patients with subjective memory impairment. Journal of Alzheimer’s Disease, 41(3), 779-791. doi: 10.3233/JAD-131889 URL pmid: 24685630
18	Erk S., Spottke A., Meisen A., Wagner M., Walter H., & Jessen F . (2011). Evidence of neuronal compensation during episodic memory in subjective memory impairment. Archives of General Psychiatry, 68(8), 845-852. doi: 10.1001/archgenpsychiatry.2011.80 URL pmid: 21810648
19	Ferreira D., Falahati F., Linden C., Buckley R. F., Ellis K. A., Savage G ., et al. Westman, E. (2017). A 'disease severity index' to identify individuals with subjective memory decline who will progress to mild cognitive impairment or dementia. Scientific Reports, 7, 44368. doi: 10.1038/srep44368 URL pmid: 5347012
20	Fletcher P. C., Shallice T., & Dolan R. J . (1998). The functional roles of prefrontal cortex in episodic memory. Brain, 121(7), 1239-1248. doi: 10.1093/brain/121.7.1239 URL pmid: 9679776
21	Fonseca J. A. S., Ducksbury R., Rodda J., Whitfield T., Nagaraj C., Suresh K ., et al. Walker, Z. (2015). Factors that predict cognitive decline in patients with subjective cognitive impairment. International Psychogeriatrics, 27(10), 1671-1677. doi: 10.1017/S1041610215000356 URL pmid: 25812703
22	Friston K. J., Frith C. D ., & Frackowiak, R. S. J. (1993). Time-dependent changes in effective connectivity measured with PET. Human Brain Mapping, 1(1), 69-79. doi: 10.1002/hbm.460010108 URL
23	Garcia-Ptacek S., Eriksdotter M., Jelic V., Porta-Etessam J., Kåreholt I., & Manzano Palomo S . (2016). Subjective cognitive impairment: Towards early identification of Alzheimer disease. Neurología (English Edition), 31(8), 562-571. doi: 10.1016/j.nrleng.2013.02.011 URL pmid: 23601758
24	Gauthier S., Reisberg B., Zaudig M., Petersen R. C., Ritchie K., Broich K ., et al. Winblad, B. (2006). Mild cognitive impairment. The Lancet, 367(9518), 1262-1270.
25	Grady C. L., Bernstein L. J., Beig S., & Siegenthaler A. L . (2002). The effects of encoding task on age-related differences in the functional neuroanatomy of face memory. Psychology and Aging, 17(1), 7-23. doi: 10.1037//0882-7974.17.1.7 URL pmid: 11931288
26	Greg A., Holly B., Roderick M. C., Hester A. L., Fields J. A., Weiner M. F ., et al. Cullum, C. M. (2007). Reduced hippocampal functional connectivity in Alzheimer disease. Archives of Neurology, 64(10), 1482-1487. doi: 10.1001/archneur.64.10.1482 URL pmid: 17923631
27	Hafkemeijer A., Altmann-schneider I., Oleksik A. M., van de Wiel L., Middelkoop H. A. M ., & van Buchem, M. A., , et al. Rombouts, S. A. R. B. (2013). Increased functional connectivity and brain atrophy in elderly with subjective memory complaints. Brain Connectivity, 3(4), 353-362.
28	Hampstead B. M., Khoshnoodi M., Yan W., Deshpande G., & Sathian K . (2016). Patterns of effective connectivity during memory encoding and retrieval differ between patients with mild cognitive impairment and healthy older adults. NeuroImage, 124(Pt A), 997-1008. doi: 10.1016/j.neuroimage.2015.10.002 URL pmid: 26458520
29	Hashimoto M., Rockenstein E., Crews L., & Masliah E . (2003). Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer’s and Parkinson’s diseases. Neuromolecular Medicine, 4(1-2), 21-35.
30	Hayes J. M., Tang L., Viviano R. P., van Rooden S., Ofen N., & Damoiseaux J. S . (2017). Subjective memory complaints are associated with brain activation supporting successful memory encoding. Neurobiology of Aging, 60(7), 71-80. doi: 10.1016/j.jalz.2016.06.175 URL pmid: 28923533
31	Hernández F., & Avila J. (2007). Tauopathies. Cellular and Molecular Life Sciences, 64(17), 2219-2233.
32	Horn M. M., Kennedy K. M., & Rodrigue K. M . (2018). Association between subjective memory assessment and associative memory performance: Role of AD risk factors. Psychology and Aging, 33(1), 109-118. doi: 10.1037/pag0000217 URL pmid: 29494182
33	Hu X., Harzem J., Huang B., Weber B., & Jessen F . (2016). Abnormal functional connectivity within default mode network in persons with subjective cognitive decline: Self-reflection of own memory deficits? Alzheimers & Dementia, 12(7), 39. doi: 10.1016/j.jalz.2016.06.1469 URL
34	Hueluer G., Hertzog C., Pearman A. M., & Gerstorf D . (2015). Correlates and moderators of change in subjective memory and memory performance: Findings from the health and retirement study. Gerontology, 61(3), 232-240. doi: 10.1159/000369010 URL pmid: 25790970
35	Hülür G., Willis S. L., Hertzog C., Schaie K. W., & Gerstorf D . (2018). Is subjective memory specific for memory performance or general across cognitive domains? Findings from the Seattle longitudinal study. Psychology and Aging, 33(3), 448-460. doi: 10.1037/pag0000243 URL pmid: 29756802
36	Jessen F., Amariglio R. E., van Boxtel M., Breteler M., Ceccaldi M., & Chételat G ., et al. Wagner, M. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers & Dementia, 10(6), 844-852. doi: 10.1016/j.jalz.2014.01.001 URL pmid: 4317324
37	Jessen F., Feyen L., Freymann K., Tepest R., Maier W., & Heun R ., et al. Scheef, L. (2006). Volume reduction of the entorhinal cortex in subjective memory impairment. Neurobiology of Aging, 27(12), 1751-1756. doi: 10.1016/j.neurobiolaging.2005.10.010 URL pmid: 16309795
38	Jessen F., Wiese B., Bachmann C., Eifflaender-Gorfer S., Haller F., Kölsch H ., et al. Rickel, H. (2010). Prediction of dementia by subjective memory impairment: Effects of severity and temporal association with cognitive impairment. Archives of General Psychiatry, 67(4), 414-422. doi: 10.1001/archgenpsychiatry.2010.30 URL pmid: 20368517
39	Kielb S., Rogalski E., Weintraub S., & Rademaker A . (2017). Objective features of subjective cognitive decline in a United States national database. Alzheimer’s & Dementia, 13(12), 1337-1344. doi: 10.1016/j.jalz.2017.04.008 URL pmid: 28586648
40	Koppara A., Wagner M., Lange C., Ernst A., Wiese B., & König H-H ., et al. Jessen, F. (2015). Cognitive performance before and after the onset of subjective cognitive decline in old age. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(2), 194-205. doi: 10.1016/j.dadm.2015.02.005 URL pmid: 27239504
41	Lam L. C. W., Lui V. W. C., Tam C. W. C ., & Chiu, H. F. K. (2010). Subjective memory complaints in Chinese subjects with mild cognitive impairment and early Alzheimer's disease. International Journal of Geriatric Psychiatry, 20(9), 876-882. doi: 10.1002/gps.1370 URL pmid: 16116581
42	Lepage M., Ghaffar O., Nyberg L., & Tulving E . (2000). Prefrontal cortex and episodic memory retrieval mode. Proceedings of the National Academy of Sciences of the United States of America, 97(1), 506-511. doi: 10.1073/pnas.97.1.506 URL pmid: 10618448
43	Meiberth D., Scheef L., Wolfsgruber S., Boecker H., Block W., Träber F ., et al. Jessen, F. (2015). Cortical thinning in individuals with subjective memory impairment. Journal of Alzheimer’s Disease, 45(1), 139-146. doi: 10.3233/JAD-142322 URL pmid: 25471190
44	Mitchell K. J., Johnson M. K., Raye C. L., & D’Esposito M . (2000). fMRI evidence of age-related hippocampal dysfunction in feature binding in working memory. Cognitive Brain Research, 10(1-2), 197-206. doi: 10.1016/S0926-6410(00)00029-X URL pmid: 10978709
45	Moscovitch M., Cabeza R., Winocur G., & Nadel L . (2016). Episodic memory and beyond: The hippocampus and neocortex in transformation. Annual Review of Psychology, 67(1), 105-134.
46	Naveh-Benjamin M. . (2000). Adult age differences in memory performance: Tests of an associative deficit hypothesis. Journal of Experimental Psychology Learning Memory and Cognition, 26(5), 1170-1187. doi: 10.1037//0278-7393.26.5.1170 URL pmid: 11009251
47	Old S.R., & Naveh-Benjamin M. (2008). Memory for people and their actions: Further evidence for an age-related associative deficit. Psychology and Aging, 23(2), 467-472. doi: 10.1037/0882-7974.23.2.467 URL pmid: 18573021
48	Park S., Ryu S. H., Yoo Y., Yang J. J., Kwon H., & Youn J. H ., et al. (2018). Neural predictors of cognitive improvement by multi-strategic memory training based on metamemory in older adults with subjective memory complaints. Scientific Reports, 8(1), 1095. doi: 10.1038/s41598-018-19390-2 URL pmid: 29348440
49	Perrotin A., La Joie R., de La Sayette V., Barré L., Mézenge F., Mutlu J ., et al. Chételat, G. (2017). Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: Differential affective and imaging correlates. Alzheimer’s & Dementia, 13(5), 550-560. doi: 10.1016/j.jalz.2016.08.011 URL pmid: 27693187
50	Perrotin A., Mormino E. C., Madison C. M., Hayenga A. O., & Jagust W. J . (2012). Subjective cognition and amyloid deposition imaging: A pittsburgh compound b positron emission tomography study in normal elderly individuals. Archives of Neurology, 69(2), 223-229. doi: 10.1001/archneurol.2011.666 URL pmid: 22332189
51	Pike K. E., Amina Z., Ben O., Sarah P., & Kinsella G. J . (2015). Reduced benefit of memory elaboration in older adults with subjective memory decline. Journal of Alzheimer’s Disease, 47(3), 705-713. doi: 10.3233/JAD-150062 URL pmid: 26401705
52	Rabin L. A., Smart C. M., Crane P. K., Amariglio R. E., Berman L. M., & Boada M ., et al. Sikkes, S. A. M. (2015). Subjective cognitive decline in older adults: An overview of self-report measures used across 19 international research studies. Journal of Alzheimer’s Disease, 48(s1), 63-86. doi: 10.3233/JAD-150154 URL pmid: 26402085
53	Rami L., Sala-llonch R., Solé-padullés C., Fortea J., Olives J., Lladó A ., et al. Molinuevo, J. L. (2012). Distinct functional activity of the precuneus and posterior cingulate cortex during encoding in the preclinical stage of Alzheimer's disease. Journal of Alzheimers Disease, 31(3), 517-526. doi: 10.3233/JAD-2012-120223
54	Reisberg B., & Gauthier S. (2008). Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease. International Psychogeriatrics, 20(1), 1-16. doi: 10.1017/S1041610207006412 URL pmid: 18072981
55	Reisberg B., Shulman M. B., Torossian C., Leng L., & Zhu W . (2010). Outcome over seven years of healthy adults with and without subjective cognitive impairment. Alzheimer’s & Dementia, 6(1), 11-24. doi: 10.1016/j.jalz.2009.10.002 URL pmid: 3873197
56	Rodda J. E., Dannhauser T. M., Cutinha D. J., Shergill S. S., & Walker Z . (2009). Subjective cognitive impairment: Increased prefrontal cortex activation compared to controls during an encoding task. International Journal of Geriatric Psychiatry, 24(8), 865-874. doi: 10.1002/gps.2207 URL pmid: 19259973
57	Rönnlund M., Sundström A., Adolfsson R., & Nilsson L.-G . (2015). Subjective memory impairment in older adults predicts future dementia independent of baseline memory performance: Evidence from the Betula prospective cohort study. Alzheimer’s & Dementia, 11(11), 1385-1392. doi: 10.1016/j.jalz.2014.11.006 URL pmid: 25667997
58	Rowe C. C., Ellis K. A., Rimajova M., Bourgeat P., Pike K. E., Jones G ., et al. Villemagne, V. L. (2010). Amyloid imaging results from the Australian imaging, biomarkers and lifestyle (AIBL) study of aging. Neurobiology of Aging, 31(8), 1275-1283. doi: 10.1016/j.neurobiolaging.2010.04.007
59	Ryu S. Y., Lim E. Y., Na S., Shim Y. S., Cho J. H., Yoon B ., et al. Yang, D. W. (2017). Hippocampal and entorhinal structures in subjective memory impairment: A combined MRI volumetric and DTI study. International Psychogeriatrics, 29(5), 785-792. doi: 10.1017/S1041610216002349 URL pmid: 28067183
60	Scheef L., Spottke A., Daerr M., Joe A., Striepens N., Kölsch H ., et al. Jessen, F. (2012). Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. Neurology, 79(13), 1332-1339. doi: 10.1016/j.jalz.2012.05.689 URL pmid: 22914828
61	Seo E. H., Kim H., Choi K. Y., Lee K. H., & Choo I. H . (2017). Association of subjective memory complaint and depressive symptoms with objective cognitive functions in prodromal Alzheimer's disease including pre-mild cognitive impairment. Journal of Affective Disorders, 217, 24-28. doi: 10.1016/j.jad.2017.03.062 URL pmid: 28380342
62	Sherry D.F., &Schacter D.L . (1987). The evolution of multiple memory systems. Psychological Review, 94(4), 439-454.
63	Sierra-rio A., Balasa M., Olives J., Antonell A., Iranzo A., Castellví M ., et al. Molinuevo, J. L. (2015). Cerebrospinal fluid biomarkers predict clinical evolution in patients with subjective cognitive decline and mild cognitive impairment. Neurodegenerative Diseases, 16(1-2), 69-76.
64	Simons J.S., &Spiers H.J . (2003). Prefrontal and medial temporal lobe interactions in long-term memory. Nature Reviews Neuroscience, 4(8), 637-648. doi: 10.1016/j.ejcts.2004.05.031 URL pmid: 12894239
65	Sluimer J. D., van der Flier, W. m., Karas G. B., Fox N. C., Scheltens P., & Barkhof F., & Vrenken H . (2008). Whole-brain atrophy rate and cognitive decline: Longitudinal MR study of memory clinic patients. Radiology, 248(2), 590-598. doi: 10.1148/radiol.2482070938 URL pmid: 18574133
66	Smart C. M., Karr J. E., Areshenkoff C. N., Rabin L. A., Hudon C., Gates N ., et al. Wesselman, L. (2017). Non-pharmacologic interventions for older adults with subjective cognitive decline: Systematic review, meta- analysis, and preliminary recommendations. Neuropsychology Review, 27(3), 245-257. doi: 10.1007/s11065-017-9342-8 URL pmid: 28271346
67	Snitz B. E., Lopez O. L., McDade E., Becker J. T., Cohen A. D., Price J. C ., et al. Klunk, W. E. (2015 a). Amyloid-β imaging in older adults presenting to a memory clinic with subjective cognitive decline: A pilot study. Journal of Alzheimer’s Disease, 48(1), 151-159. doi: 10.3233/JAD-150113 URL pmid: 26402082
68	Snitz B. E., Weissfeld L. A., Cohen A. D., Lopez O. L., Nebes R. D., Aizenstein H. J ., et al. Klunk, W. E. (2015 b). Subjective cognitive complaints, personality and brain amyloid-beta in cognitively normal older adults. American Journal of Geriatric Psychiatry, 23(9), 985-993. doi: 10.1016/j.jagp.2015.01.008 URL pmid: 25746485
69	Stewart R., Godin O., Crivello F., Maillard P., Mazoyer B., Tzourio C., & Dufouil C . (2011). Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study. British Journal of Psychiatry, 198(3), 199-205. doi: 10.1192/bjp.bp.110.078683 URL pmid: 21357878
70	Striepens N., Scheef L., Wind A., Popp J., Spottke A., Cooper-Mahkorn D ., et al. Jessen, F. (2010). Volume loss of the medial temporal lobe structures in subjective memory impairment. Dementia and Geriatric Cognitive Disorders, 29(1), 75-81. doi: 10.1159/000264630 URL pmid: 20110703
71	Swinford C. G., Risacher S. L., Charil A., Schwarz A. J., & Saykin A. J . (2018). Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 322-331. doi: 10.1016/j.dadm.2018.03.001 URL pmid: 29780876
72	Tepest R., Wang L., Csernansky J. G., Neubert P., Heun R., Scheef L., & Jessen F . (2008). Hippocampal surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer's dementia. Dementia and Geriatric Cognitive Disorders, 26(4), 323-329.
73	Tulving E. . (1995). Organization of memory: Quo vadis? Journal of Cognitive Neuroscience, 8(3), 839-853.
74	Umeda S., Akine Y., Kato M., Muramatsu T., Mimura M., Kandatsu S ., et al. Suhara, T. (2005). Functional network in the prefrontal cortex during episodic memory retrieval. NeuroImage, 26(3), 932-940. doi: 10.1016/j.neuroimage.2005.03.004 URL pmid: 15955503
75	Vannini P., Hanseeuw B., Munro C. E., Amariglio R. E., Marshall G. A., Rentz D. M ., et al. Sperling, R. A. (2017). Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden. Neurology, 88(18), 1759-1767. doi: 10.1212/WNL.0000000000003889 URL pmid: 28381517
76	Wang L., Zang Y. F., He Y., Liang M., Zhang X. Q., Tian L. X ., et al. Li, K. C. (2006). Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI. NeuroImage, 31(2), 496-504. doi: 10.1016/j.neuroimage.2005.12.033 URL pmid: 16473024

[1]	杜宇飞, 欧阳辉月, 余林. 隔代抚养与老年人抑郁水平：一项基于东西方文化背景的元分析[J]. 心理科学进展, 2022, 30(9): 1981-1992.
[2]	徐潞杰, 张镇. 老年人的消极交往与心理健康[J]. 心理科学进展, 2021, 29(8): 1472-1483.
[3]	陈浩彬, 汪凤炎. 老年人的智慧[J]. 心理科学进展, 2021, 29(5): 885-893.
[4]	程羽慧, 袁祥勇, 蒋毅. 社会互动加工的认知特性及脑机制——第三人称的视角[J]. 心理科学进展, 2021, 29(3): 472-480.
[5]	叶静, 张戌凡. 老年人心理韧性与幸福感的关系:一项元分析[J]. 心理科学进展, 2021, 29(2): 202-217.
[6]	杨伟平, 李胜楠, 李子默, 郭敖, 任艳娜. 老年人视听觉整合的影响因素及其神经机制[J]. 心理科学进展, 2020, 28(5): 790-799.
[7]	卫垌圻, 曹慧, 毕鸿燕, 杨炀. 发展性阅读障碍书写加工缺陷及其神经机制[J]. 心理科学进展, 2020, 28(1): 75-84.
[8]	何丽萍, 申寻兵, 陈振彩, 卓芮芮, 李科定, 刘振南. 老年人的微表情识别与欺骗检测[J]. 心理科学进展, 2019, 27(suppl.): 155-155.
[9]	刘迪迪, 王美萍, 陈翩, 张文新. COMT基因Val158Met多态性与抑郁的关系[J]. 心理科学进展, 2018, 26(8): 1429-1437.
[10]	孙岩, 房林, 王亭予, 崔丽. 自闭症谱系障碍者抑制控制的影响因素及神经机制[J]. 心理科学进展, 2018, 26(8): 1450-1464.
[11]	刘立敏, 田相娟, 张文新, 王美萍. MAOA基因与环境对反社会行为的交互作用及其可能的脑机制[J]. 心理科学进展, 2017, 25(6): 970-979.
[12]	钱浩悦;朱敏;高湘萍. 老年人面孔构形加工特点[J]. 心理科学进展, 2017, 25(2): 230-236.
[13]	岳童;黄希庭. 共情特质的神经生物学基础[J]. 心理科学进展, 2016, 24(9): 1368-1376.
[14]	韩笑; 石岱青; 周晓文; 杨颖华; 朱祖德. 认知训练对健康老年人认知能力的影响[J]. 心理科学进展, 2016, 24(6): 909-922.
[15]	王惠芳;蒋京川. 老年人的框架效应[J]. 心理科学进展, 2016, 24(4): 612-621.