ISSN 1671-3710
CN 11-4766/R

心理科学进展 ›› 2017, Vol. 25 ›› Issue (6): 970-979.doi: 10.3724/SP.J.1042.2017.00970

• 研究前沿 • 上一篇    下一篇

 MAOA基因与环境对反社会行为的交互作用 及其可能的脑机制

 刘立敏; 田相娟;  张文新;  王美萍   

  1.  (山东师范大学心理学院, 济南 250014)
  • 收稿日期:2016-09-13 出版日期:2017-06-15
  • 通讯作者: 王美萍, E-mail: E-mail: E-mail:
  • 基金资助:

 MAOA gene-environment interaction on antisocial behavior and its possible brain mechanism

 LIU Limin; TIAN Xiangjuan; ZHANG Wenxin; WANG Meiping   

  1.  (School of Psychology, Shandong Normal University, Jinan 250014, China)
  • Received:2016-09-13 Online:2017-06-15
  • Contact: WANG Meiping, E-mail: E-mail: E-mail:
  • Supported by:

摘要:  反社会行为具有重要的遗传学基础。MAOA基因是反社会行为的重要候选基因, 该基因与环境对反社会行为具有交互作用, 然而其内在作用机制尚不清楚。与情绪管理相关的脑区和神经回路, 以及与工作记忆能力相关的脑区和神经回路在其中起重要作用。未来研究可从多基因−环境交互作用、理论模型验证、脑结构与功能的中介作用等方面进一步深化MAOA基因与反社会行为的关系研究。

关键词:  MAOA基因, 反社会行为, 基因与环境交互作用, 脑机制

Abstract:  The existing studies have already shed light on the genetic underpinnings of antisocial behavior. MAOA gene is an important candidate gene of antisocial behavior. It has been demonstrated that the effect of MAOA gene on antisocial behavior is moderated by environment, however, its underlying mechanism remains unclear. The brain regions and neural circuits associated with emotional management, as well as related to working memory capacity might play an important role. Future research could focus on the issues of polygene-environment interaction, the validation of theoretical model on gene-environment interaction, and the possible mediating role of brain structure and functions.

Key words:  MAOA gene, antisocial behavior, gene-environment interaction, brain mechanism