ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

心理科学进展 ›› 2019, Vol. 27 ›› Issue (1): 60-69.doi: 10.3724/SP.J.1042.2019.00060

• 研究前沿 • 上一篇    下一篇

奖赏环路与阿片成瘾:喙内侧被盖核的调节作用

吴静1, 崔睿思1, 孙翠翠2, 李新旺1()   

  1. 1 首都师范大学心理学院, 北京 100037
    2 华中师范大学心理学院, 武汉 430079
  • 收稿日期:2018-05-03 出版日期:2019-01-15 发布日期:2018-11-23
  • 基金资助:
    * 国家自然科学基金项目(31470989)

Reward circuits and opioid addiction: The moderating effect of the rostromedial tegmental nucleus

WU Jing1, CUI Ruisi1, SUN Cuicui2, LI Xinwang1()   

  1. 1 School of Psychology, Capital Normal University, Beijing 100037, China
    2 School of Psychology, Central China Normal University, Wuhan 430079, China
  • Received:2018-05-03 Online:2019-01-15 Published:2018-11-23

摘要:

喙内侧被盖核(RMTg)位于腹侧被盖区(VTA)的尾部, 富含抑制性的γ-氨基丁酸(GABA)能神经元.RMTg是中脑边缘多巴胺系统的一个综合调节器.它的GABA能神经元接受外侧缰核(LHb)的输入, 然后投射到VTA多巴胺能神经元, 进而抑制多巴胺的释放.这三个脑区是奖赏环路的重要组成部分, 其中RMTg在阿片类物质激活的奖赏环路中尤为重要.阿片类物质主要通过抑制RMTg GABA能神经元使VTA多巴胺能神经元去抑制, 进而激活奖赏系统.因此, RMTg有望成为治疗药物成瘾(尤其是阿片成瘾)的一个重要靶点.此外, 胆碱类物质作用于RMTg的毒蕈碱受体能够抑制阿片类物质诱导的奖赏效应.未来研究应深入探讨RMTg调控的负性奖赏环路, 这对弱化觅药动机,促进消退和戒断具有重要意义.

关键词: 奖赏环路, 喙内侧被盖核, GABA能神经元, 外侧缰核, 阿片成瘾

Abstract:

The rostromedial tegmental nucleus (RMTg) is located caudally to the ventral tegmental area (VTA), which is rich in inhibitory γ-aminobutyric acid (GABAergic) neurons. The RMTg is an integrative modulator of the mesolimbic dopamine system. Its GABAergic neurons receive input from the lateral habenula (LHb) and then project to VTA dopaminergic neurons, which inhibits the release of dopamine. These three brain areas are an important part of the reward circuit, in which the RMTg plays a particularly important role in reward circuits activated by opioids. GABA neurons in the RMTg are strongly inhibited by opioids, and this is followed by disinhibition of VTA dopaminergic neurons, which activates the reward system. Therefore, the RMTg is a potentially important target for the treatment of drug addiction (especially opioid addiction). Furthermore, cholinergic feedback to the RMTg, acting on muscarinic receptors, can be inhibitory for an opioid-induced reward effect. Future studies should further explore the negative reward circuit regulated by the RMTg, which is of great significance for weakening drug-seeking motivation and promoting extinction and withdrawal.

Key words: reward circuits, rostromedial tegmental nucleus, GABAergic neurons, lateral habenula, opioid addiction

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