ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

›› 2006, Vol. 14 ›› Issue (6): 907-911.

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Long-term Effects of Early-life Stress on Behavioral and Neuroendocrine Changes Associated with Depression

Wang Weiwen;Shao Feng;Liu Mei;Lin Wenjuan   

  1. Key Lab of Mental Health, Chinese Academy of Sciences, Beijing, 100101, China
  • Received:2006-01-30 Revised:1900-01-01 Online:2006-11-15 Published:2006-11-15
  • Contact: Lin Wenjuan

Abstract: Clinical studies indicate early traumatic experiences are high risk factors in the development of depression in adulthood. The pathways that mediate the long-term effects of early-life stress on pathophysiology of depression are still unclear. This article reviewed laboratory animal studies in which the early-life stress models and the stress-induced chronic behavioral and neurobiological changes associated with depression were examined. It is concluded that early-life stress influenced behavior implicated in motivation for reward and stress coping, but it didn’t influence intrinsic behavior. These findings further demonstrated that early-life stress affected the development of depression by increasing individual predisposition to depression

Key words: early-life stress, depression, behavior, neuroendocrine

CLC Number: