Abstract: The present paper started with introduction to 7 dimensions of biosocial personality model proposed by Cloninger. The empirical evidences to this model regarding neurotransmitter, genetics, index of cerebral blood flow and EEG were reviewed. The relationship between Cloninger’s model and other biological models of personality were thoroughly discussed, especially, the difference between Cloninger’s model and Eysenck’s model was compared in-depth. Last, the author commented on Cloninger’s model, and proposed that investigating the interaction between biological mechanism, environment and individual behavior could become a future trend of personality studies

Key words: Personality, biosocial mode, biological mechanism