ISSN 1671-3710
CN 11-4766/R

Advances in Psychological Science ›› 2020, Vol. 28 ›› Issue (12): 2027-2039.doi: 10.3724/SP.J.1042.2020.02027

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Establishment and evaluation of animal pre-attentive processing models: Based on the MMN deficit in mental disorders

WANG Sheng, CHEN Yahong, WANG Jinyan()   

  1. CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
    Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2020-03-11 Online:2020-12-15 Published:2020-10-26
  • Contact: WANG Jinyan


Pre-attentive processing refers to the early and automatic cognitive processes which are independent of consciousness and do not demand attention. Auditory mismatch negativity (MMN) is the most commonly used indicator of pre-attentive processing. MMN deficits have been found in a various of mental disorders, but little is known about the neurobiological mechanisms of MMN deficits. Combined with highly developed neurobiological and pharmacological techniques, animal models can provide valuable insights into the underlying mechanisms of MMN. Future animal studies of MMN should give more thoughts to the biological characteristics of different species and compare MMN across species in combination with human and animal research advantages. Hopefully, this comparative approach will lead to a better understanding of pre-attentive processing at both the macro and the micro levels.

Key words: rodent, pre-attentive processing, MMN, schizophrenia

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