COMT基因Val158Met多态性与抑郁的关系

doi:10.3724/SP.J.1042.2018.01429

摘要/Abstract

摘要：

抑郁的发生具有重要的遗传学基础。COMT基因Val158Met多态性是抑郁的重要候选基因位点。目前有关COMT基因Val158Met多态性与抑郁关系的研究主要采用单基因设计、单基因-环境设计以及多基因-环境设计。有资料显示负性情绪偏向及其相关脑区可能在COMT基因Val158Met多态性与抑郁间起中介作用, 但具体机制仍有待探究。未来研究可以进一步考察被试的种族、年龄和性别等因素对COMT基因Val158Met多态性与抑郁关系的调节作用, 并通过采用多基因-环境设计, 综合运用积极与消极环境指标等措施深入考察负性情绪偏向和相关脑区在COMT基因Val158Met多态性与抑郁间的作用及其机制。

关键词: COMT基因, 抑郁, 负性情绪偏向, 脑机制, Val158Met多态性

Abstract:

The development of depression has important genetic underpinnings. COMT (catechol-O- methyltransferase) Val158Met polymorphism is an important candidate gene locus for depression. At present, the studies associated with the relationship between COMT Val158Met polymorphism and depression mainly adopt single gene design, single gene-environment design and multiple gene-environment design. The researches have demonstrated that negativity bias and its related brain mechanism may play an intermediary role between COMT Val158Met polymorphism and depression. However, the mechanism underlying is still not clear and need to be explored. Future research should focus on issues as the moderation effect of participants’ ethnicity, gender and age on the association between COMT Val158Met polymorphism and depression, and further investigate the role of negativity bias and the neuralbiological mechanisms between COMT Val158Met polymorphism and depression by using multiple gene-environment design and comprehensively using positive and negative environmental factors.

Key words: COMT gene, depression, negativity bias, brain mechanism, Val158Met polymorphism

中图分类号:

B845

刘迪迪, 王美萍, 陈翩, 张文新. (2018). COMT基因Val158Met多态性与抑郁的关系. 心理科学进展 , 26(8), 1429-1437.

LIU Didi, WANG Meiping, CHEN Pian, ZHANG Wenxin. (2018). Association between COMT Val158Met polymorphism and depression. Advances in Psychological Science, 26(8), 1429-1437.

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