ISSN 1671-3710
CN 11-4766/R
主办:中国科学院心理研究所
出版:科学出版社

›› 2011, Vol. 19 ›› Issue (5): 652-663.

• 研究前沿 • Previous Articles     Next Articles

Research Paradigms and Neural Mechanisms for Decision-making Deficits in Addicts

YAN Wan-Sen;LI Shu;SUI Nan   

  1. (1Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China)
    (2Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China)
    (3Graduate University of the Chinese Academy of Sciences, Beijing 100049, China)
  • Received:2011-01-05 Revised:1900-01-01 Online:2011-05-15 Published:2011-05-15
  • Contact: SUI Nan

Abstract: Drug addicts and pathological gamblers usually prefer immediate reward and ignore the future consequences. They are inclined to choose the bad options those bring immediate gains but long-term losses, which implies a kind of decision-making deficits. The Delay Discounting Task (DDT), the Iowa Gambling Task (IGT) and the Cambridge Gamble Task (CGT) are mainly three typical research paradigms and methods on decision -making deficits including impulsivity, myopia and risk-taking in addicts. Studies in recent years have demonstrated that the prefrontal cortex (PFC) plays an important role in human decision-making, such as the ventromedial prefrontal cortex (VMPFC), the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (DLPFC). Future directions in this area are introduced and anticipated.

Key words: addiction, decision-making deficit, delay discounting, gambling task, PFC