ISSN 1671-3710
CN 11-4766/R

Advances in Psychological Science ›› 2015, Vol. 23 ›› Issue (7): 1187-1195.doi: 10.3724/SP.J.1042.2015.01187

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Neural Circuits of Orbitofrontal Cortex Involved in Suicidal Attempts Among Major Depression Patients

LI Huanhuan; Xie Weizhen; LI Yongna   

  1. (Department of Psychology, Renmin University of China, Beijing 100872, China)
  • Received:2014-10-30 Online:2015-07-15 Published:2015-07-15
  • Contact: LI Huanhuan, E-mail:; LI Yongna, E-mail:


For a suicidal person, suicide seems to be the only means of escaping the torment of psychological pain. Pain avoidance, representing the wish to escape psychological pain, may be a primary predictor of subsequent suicide. Given that the Orbitofrontal cortex dysfunction may trigger overreaction to a social signal of disapproval (painful feelings) and induced high level motivation for escaping from punishment (pain avoidance), event-related functional MRI was used to measure orbitofrontal cortex and its neural circuit activity in response to stimuli representing negative/positive emotional incentives among patients with a history of suicidal attempts ( suicidal history) in furture work. Our work will extend interactive modes of motivation and cognitive control circuits underying higher levels of psychological pain and ultimately may provide a empiral evidence for the neural correlates of pain avoidance which trigger suicidal behavior.

Key words: suicidal attempt, depression, psychological pain, pain avoidance, orbitofrontal cortex