ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2014, Vol. 22 ›› Issue (1): 75-85.doi: 10.3724/SP.J.1042.2014.00075

• 研究前沿 • 上一篇    下一篇

新颖寻求特质对药物成瘾易感性的影响及其机制

田琳;李新旺;杨钒;赵钰丹   

  1. 首都师范大学心理系, 北京市“学习与认知”重点实验室, 北京 100048
  • 收稿日期:2013-04-09 出版日期:2014-01-15 发布日期:2014-01-15
  • 通讯作者: 李新旺

The Effect of Novelty Seeking Behavioral Trait on Susceptibility to Drug Addiction and Its Neurobiological Mechanisms

TIAN Lin;LI Xinwang;YANG Fan;ZHAO Yudan   

  1. Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, Beijing 10048, China
  • Received:2013-04-09 Online:2014-01-15 Published:2014-01-15
  • Contact: LI Xinwang

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摘要：

新颖寻求特质是个体对新颖刺激或潜在的奖赏线索表现出愉悦或兴奋的先天倾向, 并且这种先天倾向会导致个体为寻求潜在的奖赏进行频繁的探索性活动。众多研究表明, 新颖寻求水平高的个体药物成瘾易感性高。多巴胺、5-羟色胺、谷氨酸、γ-氨基丁酸、胆囊收缩素、成纤维细胞生长因子及皮质酮可能参与了新颖寻求特质影响药物成瘾易感性的过程。未来, 仍需对新颖寻求特质影响药物成瘾易感性的神经生物学机制进行深入研究。

关键词: 新颖寻求, 药物成瘾, 感觉寻求, 创造性

Abstract:

Novelty seeking behavioral trait refers to a heritable tendency toward intense exhilaration or excitement when responding to novel stimuli or cues of potential reward, which results in frequent exploratory activity in pursuing potential reward. Extensive studies indicate that high level of novelty seeking behavioral trait is associated with increased susceptibility to drug addiction. Dopamine, serotonin, glutamic acid, γ-aminobutyric acid, cholecystokinin, fibroblast growth factor and corticosterone may be involved in the effect of novelty seeking behavioral trait on susceptibility to drug addiction. In the future, further studies will be focused on neurobiological mechanisms underlying the effect of novelty seeking behavioral trait on susceptibility to drug addiction.

Key words: novelty seeking, drug addiction, sensation seeking, creativity