ISSN 1671-3710
CN 11-4766/R

心理科学进展 ›› 2017, Vol. 25 ›› Issue (12): 2036-2042.doi: 10.3724/SP.J.1042.2017.02036

• 生理心理学专栏 • 上一篇    下一篇


 张 瑜1,2,3;  林文娟1,2;  王玮文1,2   

  1.  (1中国科学院心理健康重点实验室, 中国科学院心理研究所, 北京 100101) (2中国科学院大学, 北京 100049) (3滨州医学院护理学院, 烟台 264003)
  • 收稿日期:2017-04-05 出版日期:2017-12-15 发布日期:2017-10-25
  • 通讯作者: 王玮文, E-mail:
  • 基金资助:
     国家自然科学基金(No. 81471122 and No. 31470988), 中国科学院(KJZD-EW-L04)和中国科学院心理健康重点实验室(中国科学院心理研究所)资助。

 Imbalance of central immunity and cognitive dysfunction: The role of TNFα

 ZHANG Yu1,2,3; LIN Wenjuan1,2; WANG Weiwen1,2   

  1.  (1 CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing 100101, China) (2 University of Chinese Academy of Sciences, Beijing 100049, China) (3 School of Nursing, Binzhou Medical University, Yantai 264003, China)
  • Received:2017-04-05 Online:2017-12-15 Published:2017-10-25
  • Contact: WANG Weiwen, E-mail:
  • Supported by:

摘要:  中枢免疫对于神经系统内稳态的维持意义重大。免疫活性分子TNFα及其受体系统参与神经发育、突触可塑性和认知功能调节; 其表达异常, 无论过度或者不足都可能导致对脑功能和行为的不良影响。应激, 尤其是发育早期应激可能通过影响中枢TNFα的动态发展过程从而造成其功能的持续改变, 并与后期免疫相关的心理病理发生密切相关。未来研究需拓展中枢免疫与认知功能障碍之间的因果联系, 建立基于免疫调节的疾病防治新策略。

关键词: 内稳态, TNFa, 应激, 突触可塑性, 认知功能

Abstract:  Central immune activities exert important roles in maintaining homeostatic process of central nervous system. It has shown that the dynamically balance of brain TNFα participates in the regulation of neurodevelopment, synaptic plasticity and cognitive function by its receptor signaling, while imbalance of TNFα signaling, no matter excessive or insufficient, can result in adverse effects on brain function and behavior. Stress, especially early stress, may disturb the dynamic development process of TNFα signaling and thus cause lasting alterations of its expression and receptor function, which strongly linked to the increasing incidences of immune-related psychopathological disorders in late life. Future studies are needed to deepen the understanding of causal relationships between central immunity and cognitive dysfunction, and establish new strategies for disease prevention and treatment based on immunoregulation.

Key words: homeostasis, Tumor necrosis factor (TNFa), stress, synaptic plasticity, cognitive function