Intelligent technology provides new opportunities for the research and applications of engineering psychology. To this end, a work framework of engineering psychology in the intelligent era is proposed. The framework includes the objectives of engineering psychology research and applications, core problem space, disciplinary philosophy, focus of research and applications, methods and so on. The human-machine relationship in the intelligent era has presented a new form: the human-machine cooperation in the form of human-machine teaming. “Human-centered artificial intelligence” should be the discipline philosophy of engineering psychology in the intelligent era. Aiming at intelligent technology, engineering psychology researchers have recently begun to carry out research work on the theoretical framework and basic issues surrounding the new human-machine relationship, mental construct, shared decision-making between human and machine, and the interaction design for intelligent systems. In order to effectively support the research and development of intelligent systems, new and enhanced methods of engineering psychology are summarized. Finally, specific suggestions are given for addressing the challenges faced by engineering psychology.