Please wait a minute...
   2011, Vol. 19 Issue (7) : 944-958     DOI:
博士论坛 |
Animal Model and Neural Mechanisms of Top-Down Modulation of Auditory Sensorimotor Gating
DU Yi;LI Liang
Department of Psychology, Speech and Hearing Research Center, Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing 100871, China
Download: PDF(534 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    

Prepulse inhibition (PPI), which reflects the important mechanisms inhibiting interference and protecting information processing, is widely recognized as a model for studying both sensorimotor gating and schizophrenia. PPI can be top-down modulated by higher-order cognitive processes, such as attention and emotion. This dissertation focuses on the hierarchically organized top-down modulation of PPI by fear conditioning and perceptual spatial separation (selective spatial attention). Systematic and cross-level researches on rat behavioral model, neural pathways, and neurophysiological mechanisms were conducted, and the neuro-developmental model of schizophrenia was also applied which demonstrates that isolation rearing in rats can disrupt the attentional modulation of PPI. The findings from this research will not only promote the understanding of the brain mechanisms in information processing under complex environment, the animal model based on deficient attention-on-gating modulation function will also advance the psychological and neurobiological research on schizophrenia.

Keywords Prepulse inhibition      Attentional modulation      Fear conditioning      Perceptual spatial unmasking      Schizophrenia     
Corresponding Authors: LI Liang   
Issue Date: 15 July 2011
E-mail this article
E-mail Alert
Articles by authors
LI Liang
Cite this article:   
DU Yi,LI Liang. Animal Model and Neural Mechanisms of Top-Down Modulation of Auditory Sensorimotor Gating[J]. , 2011, 19(7): 944-958.
URL:     OR
[1] LIANG Tengfei; LIU Qiang; HU Zhonghua. Bilateral field advantage and its brain mechanism during visual processing[J]. Advances in Psychological Science, 2016, 24(7): 1032-1041.
[2] ZHENG Panpan; LYU Zhenyong; Todd JACKSON. The acquisition, generalization and extinction of fear of pain[J]. Advances in Psychological Science, 2016, 24(7): 1065-1076.
[3] ZHU Chuan-Lin; Li Ping; Luo Wen-Bo; Qi Zheng-Yang; He Wei-Qi. Emotion regulation in schizophrenia[J]. Advances in Psychological Science, 2016, 24(4): 556-572.
[4] GUO Yafei; JIN Shenghua; WANG Jianping; WU Linhua; AIDI Ma. Changes of Schizophrenia Spectrum Disorder in DSM-5: #br# Dispute between Categorical and Dimensional Approaches[J]. Advances in Psychological Science, 2015, 23(8): 1428-1436.
[5] WU Chao;WU Xihong;LI Liang. Speech Recognition in Schizophrenic under Masking Conditions[J]. Advances in Psychological Science, 2013, 21(6): 958-964.
[6] XUE Xiaofang;LI Man;WANG Weiwen;SHAO Feng. The Animal Model and Neurobiological Mechanisms of Maternal Separation[J]. Advances in Psychological Science, 2013, 21(6): 990-998.
[7] WANG Yu-Na;CHAN Raymond. Self Impairment and Schizophrenia[J]. , 2010, 18(12): 1882-1891.
[8] SHI Yan-Fang;CHAN Raymond C. K.. Anhedonia in Schizophrenia Spectrum Disorders[J]. , 2010, 18(09): 1430-1439.
[9] LI Liang;LI Nan-Xin. Establishing New Animal Models for Studying Schizophrenia[J]. , 2008, 16(03): 399-403.
[10] WU Run-Guo;; LUO Yue-Jia. The Neural Basis of the Emotional Memory[J]. , 2008, 16(03): 458-463.
[11] AN Xian-Li;ZHENG Xi-Geng.

The Animal Models and Neurobiological Mechanisms of Posttraumatic Stress Disorder

[J]. , 2008, 16(03): 371-377.
[12] SHAO Feng;WANG Wei-Wen;LIU Mei;JIN Jian. Latent Inhibition as an Animal Model of Schizophrenia[J]. , 2008, 16(03): 392-398.
[13] Mo Shuliang;Chen Chuqiao. Perception and Recognition of Facial Expressions of Emotion in Schizophrenia[J]. , 2008, 16(02): 266-273.
[14] Zhu Chunyan,Wang Kai,Lee TMC. Executive Function and Schizophrenia[J]. , 2004, 12(05): 743-751.
[15] Wang Yiniu,Luo Yuejia. Emotional Disorders in Patients with Prefrontal Cortex Lesions[J]. , 2004, 12(02): 161-167.
Full text



Copyright © Advances in Psychological Science
Support by Beijing Magtech