右腹外侧前额叶对高抑郁水平成年人社会情绪调节的作用：一项tDCS研究

doi:10.3724/SP.J.1041.2019.00207

摘要/Abstract

摘要：

已有的经颅直流电刺激(transcranial direct current stimulation, tDCS)研究证明, 右腹外侧前额叶(right ventrolateral prefrontal cortex, RVLPFC)是社会情绪调节的重要脑区, 激活RVLPFC可显著降低人们对社会性负性情绪体验的强度。社会功能受损是抑郁症患者或抑郁倾向人群的重要特征之一。该群体对社会排斥的敏感性高, 且对负性社会情绪体验的情绪调节能力降低。在本研究中, 我们采用外显的情绪调节任务, 研究了高、低抑郁水平的两组成年人被试在RVLPFC接受阳性tDCS后其情绪调节能力的改变。结果表明, 虽然采用tDCS激活RVLPFC可帮助被试通过情绪调节(认知重评)减弱负性情绪体验, 但高抑郁水平被试的负性情绪强度下降程度明显小于低抑郁水平被试。另外本文还发现, 与源于个人的负性情绪相比, tDCS效应对源于社会的负性情绪(即社会排斥)更强。本研究是采用电或磁刺激提高抑郁人群社会情绪调节能力的首次尝试。实验结果表明, 高抑郁水平成年人的RVLPFC仅通过单次、短时间(34 min)的tDCS激活, 其情绪调节能力并未得到显著提升。这提示对抑郁倾向群体或抑郁症患者的干预或治疗需要多次施加tDCS。

关键词: 抑郁倾向, 经颅直流电刺激, 右腹外侧前额叶, 社会排斥, 负性情绪

Abstract:

So far as we know, three studies demonstrated that that the right ventrolateral prefrontal cortex (RVLPFC) plays an important role in down-regulating the emotional response to social exclusion. In a previous study, we explored the causal relationship between transcranial direct current stimulation (tDCS) and dominant emotional regulation in the context of social exclusion. Depression is an disorder that shows deficits of social functions. Compared with healthy controls, depressive individuals enjoy less in social interaction and the activation of the lateral prefrontal lobe of depressive subjects usually reduces. The current study aimed to explore whether the anodal tDCS targeting at RVLPFC could also improve the emotional regulation of social exclusion in subjects with high depressive levels. Furthermore, this study added individual negative images as a baseline to test the specificity of the RVLPFC on emotional regulation of social exclusion.
Before the experiment, we classified the participants with a Beck Depression Inventory score of < 3 as low depressive tendency group and those with a score of ≥ 18 as high depression tendency group. Participants also completed a Self-Rating Depression Scale (SDS) on the day of the tDCS experiment. Finally, a total of ninety-eight participants were included. They were randomly divided into anodal tDCS group (including 25 high depressive and 25 low depressive subjects) and sham tDCS group. All participants viewed social exclusion images and individual negative images separately in two blocks. In the no-reappraisal condition, participants were instructed to passively view images; in the reappraisal condition, they reappraised images so to down-regulate the negative emotional responses. Ratings of negative emotion experience were provided at the end of each trial.
There was a significant three-way interaction of group, tDCS type, and task. Simple simple effect analysis showed that in the reappraisal condition, anodal tDCS over the RVLPFC resulted in a decreased negative emotion rating in subjects with low-depressive levels, while this task effect (i.e., emotional regulation) was not significant in subjects with high-depressive levels. Another three-way interaction was found among image type, tDCS type, and task: when participants were presented with social exclusion images, in the reappraisal condition, anodal tDCS over the RVLPFC resulted in a decreased negative emotion rating in the emotional regulation condition; however this task effect was less significant when participants were presented with individual negative images. Besides the two three-way interactions, this study also observed significant main effects of task, group, and tDCS type, as well as two-way interactions of group and task, tDCS type and task, image type and task, and group and tDCS type.
The current findings indicate that the improvement of emotion regulation via tDCS targeting at RVLPFC may be invalid for depressive patients if only one session of tDCS is performed; thus multiple sessions are highly suggested for clinical practice. Furthermore, this is the first tDCS study that compared the RVLFPC role of emotional regulation of social versus individual based negative experiences. The result provides evidence of direct causal relationship between RVLPFC and emotional regulation in the context of social exclusion, highlighting the functional specificity of this brain region on emotional regulation.

Key words: depression tendency, transcranial direct current stimulation, right ventrolateral prefrontal cortex, social exclusion, negative emotion

中图分类号:

B845
R395

张丹丹, 刘珍莉, 陈钰, 买晓琴. (2019). 右腹外侧前额叶对高抑郁水平成年人社会情绪调节的作用：一项tDCS研究. 心理学报, 51(2), 207-2015.

ZHANG Dandan, LIU Zhenli, CHEN Yu, MAI Xiaoqin. (2019). The role of right ventrolateral prefrontal cortex on social emotional regulation in subclinical depression: An tDCS study. Acta Psychologica Sinica, 51(2), 207-2015.

图/表 3

表1 本研究四组被试的人口学特征(M ± SD)

变量	低抑郁倾向 tDCS阳性刺激 (n = 25)	高抑郁倾向 tDCS阳性刺激 (n = 25)	低抑郁倾向 tDCS伪刺激 (n = 26)	高抑郁倾向 tDCS伪刺激 (n = 22)
年龄	20.73 ± 2.47	21.73 ± 3.65	21.55 ± 3.22	20.89 ± 2.21
性别, 男/女	13/13	13/11	13/12	12/11
SDS	0.45 ± 0.04	0.57 ± 0.08	0.43 ± 0.05	0.54 ± 0.09
STAI-T	41.82 ± 6.67	41.81 ± 4.62	40.88 ± 6.09	42.23 ± 3.65

图1 实验流程示意图。A, 实验材料示例。B, 单个试次中刺激的呈现(以个体负性图片为例)。

图2 负性情绪强度评定结果。A, 任务、组别和tDCS类型的三重交互作用。B, 任务、图片类型和tDCS类型的三重交互作用。图中的误差条(error bar)表示标准误。*p < 0.05, **p < 0.01, ***p < 0.001。

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