ISSN 0439-755X
CN 11-1911/B
主办：中国心理学会
　　　中国科学院心理研究所
出版：科学出版社

心理学报 ›› 1990, Vol. 22 ›› Issue (3): 68-74.

• • 上一篇    下一篇

背侧海马注射神经递质受体激动剂及阻断剂对大鼠条件反射的影响

齐慧新;王玢   

  1. 北京师范大学生物系,北京师范大学生物系 中国医学科学院基础医学研究所生理研究室
  • 发布日期:1990-09-25 出版日期:1990-09-25
  • 通讯作者: 齐慧新

EFFECTS OF INTRADORSACHIPPOCAMPAL MICROINJECTION OF SOME TRANSMITTERS RECEPTOR AGONIST AND ANTAGONIST ON OPERANT DEFENSE CONDITIONING IN RATS

Qi Huixin;Wang Bin Department of Biology, Beijing Normal University   

  • Online:1990-09-25 Published:1990-09-25

被引次数

4

摘要： 本工作应用脑内埋植慢性导管进行微量注射的方法,研究了背侧海马内注射乙酰胆碱及其M-受体阻断剂阿托品,GABA及其受体阻断剂印防己毒素,L-谷氨酸及其受体阻断剂4-羟基喹啉酸和受体激动剂海人酸、喹啉酸对大鼠巩固的操作式防御性条件反射的影响。结果表明:(1)乙酰胆碱、低浓度的印防己毒素、L-谷氨酸、海人酸、喹啉酸均对动物条件反射有暂时的促进作用。(2)阿托品、GABA和4-羟基喹啉酸均对动物条件反射有暂时的抑制作用。这些结果提示:海马内几种神经递质系统可能参与大鼠记忆再现的调制。

关键词: NULL

Abstract: We adopted the method of embeding the chronic canal in brain tomicroinject Acetylcholine and Atropine, GABA and Picrotoxin, L-Glutam-ate and receptor agonist kainic acid, Quinolinic acid, antagonist kynare-nic acid to dorsal hippocampus. The effects of such injection on the con-solidatory operant defence conditioning in rats were investigated. Theresults showed: (1 ) Acetylcholine, low concentration of picrotoxin, L-Glutamate,kainicacid and Quinolinic acid improved the complication of conditionedreflect activity. (2 ) Atropine, GABA and kynurenic acid impaired the above mentio-ned activity. These results suggested that some transmitter system in thehippocampus may be involved in memory retrieval modulation in rats.

Key words: NULL