ISSN 0439-755X
CN 11-1911/B
主办:中国心理学会
   中国科学院心理研究所
出版:科学出版社

心理学报 ›› 1983, Vol. 15 ›› Issue (3): 101-107.

• • 上一篇    下一篇

损毁下丘脑弓状核、中缝背核和蓝斑对大鼠应激镇痛的影响

印其章;郭试瑜;邸石;于烽生   

  1. 苏州医学院 ,苏州医学院 ,苏州医学院,苏州医学院 北京医学院精神卫生研究所 ,广州医学院附属第一医院呼吸病研究所
  • 出版日期:1983-09-25 发布日期:1983-09-25
  • 通讯作者: 印其章

EFFECTS OF LESION OF HYPOTHALAMIC ARCUATE NUCLEUS,DORSAL RAPHE NUCLEUS AND LOCUS COERULEUS ON STRESS-INDUCED ANALGESIA IN RATS

Yin Qi-zhang,Guo Shi-yu,Di Shi and Yu Feng-sheng (suzhou Medical College,Suzhou)   

  • Online:1983-09-25 Published:1983-09-25

摘要: 本文用不能躲避的间歇脚底电刺激引起大鼠应激,用电刺激鼠尾-嘶叫法测定镇痛效应,研究下丘脑弓状核(脑内β-内啡肽能神经元胞体集中的部位)、中缝背核(脑内5-羟色胺能神经元胞体主要集中的部位之一)和蓝斑(脑内去甲肾上腺素能神经元胞体主要集中的部位之一)与应激镇痛的关系。 用新生大鼠腹腔注射谷氨酸-钠的方法损毁弓状核后,用海人酸和电解两种方法损毁中缝背核或蓝斑后,应激镇痛效应均明显减弱。由于谷氨酸-钠和海人酸只选择性地损毁神经元胞体,故认为脑内的β-内啡肽能神经元、5-羟色胺能神经元和去甲肾上腺素能神经元均参与应激的行为镇痛。

关键词: NULL

Abstract: It is well known that the β-endorphin-containing neurons,serotonin-containing neurons and noradrenaline-containing neurons are concentrated inhypothalamic arcuate nucleus,dorsal raphe nucleus and locus coeruleusrespectively.In this study the effects of lesion of these three nuclei onstress-induced analgesia were investigated in rats.Stress was produced byinescapable intermittent footshock,and the analgesic effect was measuredby tail stimulation-vocalization test. After monosodium glutamate-induced arcuate nuclear lesion and kainicacid-induced lesion or electrolytic lesion of dorsal raphe nucleus and locuscoeruleus,the analgesic effect of footshock stress was decreased significantly.It is suggested that β-endorphin-,serotonin-and noradrenaline-containingneurons might play an important role in stress-induced analgesia.

Key words: NULL