ISSN 0439-755X
CN 11-1911/B

心理学报 ›› 2023, Vol. 55 ›› Issue (4): 556-571.doi: 10.3724/SP.J.1041.2023.00556

• 研究报告 • 上一篇    下一篇


卓利楠1,, 曾祥玉1,, 吴冰1, 牛荣荣1, 于萍1(), 王玮文2()   

  1. 1北京市“学习与认知”重点实验室; 首都师范大学心理学院, 北京 100048
    2中国科学院心理健康重点实验室, 中国科学院心理研究所, 北京 100101
  • 收稿日期:2022-03-22 发布日期:2022-12-30 出版日期:2023-04-25
  • 通讯作者: 于萍,王玮文;
  • 作者简介:卓利楠和曾祥玉为共同第一作者
  • 基金资助:

The function of mPFC-NAc circuit in decision impulsivity: A study based on an animal model

ZHUO Linan1,, ZENG Xiangyu1,, WU Bing1, NIU Rongrong1, YU Ping1(), WANG Weiwen2()   

  1. 1Beijing Key Laboratory of Learning and Cognition, School of Psychology, Capital Normal University, Beijing 100048, China
    2Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
  • Received:2022-03-22 Online:2022-12-30 Published:2023-04-25
  • Contact: YU Ping, WANG Weiwen;


注意缺陷多动障碍(attention deficit/hyperactivity disorder, ADHD)行为控制不足与决策冲动密切相关, 后者受内侧前额皮层(medial prefrontal cortex, mPFC)与伏隔核(nucleus accumbens, NAc)调节。为调查ADHD决策冲动与mPFC-NAc间功能耦合的关系, 研究采用ADHD模型SHR (spontaneously hypertensive rat, SHR)大鼠, 结合延迟折扣任务和在体电生理, 研究发现, 与对照Wistar (WIS)大鼠相比, SHR大鼠对延迟大奖赏的选择百分比降低; WIS大鼠mPFC-NAc的Theta频段相干值表现为延迟选择时显著大于立即选择时、首次选择时大于连续选择时、转换试次时大于连续试次时, 而SHR大鼠在上述条件均低于WIS大鼠。回归分析发现mPFC-NAc的相干差值与延迟大奖赏选择率显著正相关。结果表明mPFC-NAc间功能联系减弱是ADHD决策冲动缺陷的重要环路基础, 该缺陷与其深度信息加工以及策略转换能力受损有关, 扩展了ADHD决策冲动的认知和神经机制的认识。

关键词: 注意缺陷多动障碍, 决策冲动, 内侧前额皮层, 伏隔核, 神经振荡


Insufficient behavior control in patients with attention deficit / hyperactivity disorder (ADHD) is closely related to decision impulsivity, which is regulated by medial prefrontal cortex (mPFC) and nucleus accumbens (NAc). In ADHD patients, the mPFC and NAc show abnormality both structurally and functionally, indicating that these two brain regions are involved in regulation of decision-making, especially impulsivity. Although extensive anatomical connections between mPFC and NAc have been found, the role of mPFC-NAc circuit in decision impulsivity remains to be investigated.

Wistar (WIS) rats and ADHD rats (SHR, spontaneously hypertensive rat) were used as subjects of this study. We recorded the local field potential (LFP) of mPFC and NAc using multi-channel electrophysiology during a delay discounting task (DDT). We further analyzed the coherence difference of Theta (4~12 Hz) oscillation in expectation period (0~3s) and compared this measure between the two groups.

Results: (1) SHR rats had higher decision impulsivity level than WIS group. Power spectral density between 6~12 Hz of LFP in mPFC and NAc increased in both groups. (2) When choosing large/delayed rewards, coherence of mPFC-NAc activity increased compared to small/immediate rewards in WIS group. This indicates that the mPFC-NAc circuit mediates decision impulsivity. (3) When choosing large/delayed rewards, mPFC-NAc activity in SHR group showed lower coherence than WIS group, indicating SHR rats have weaker mPFC-NAc functional connections. (4) Coherence of mPFC-NAc activity is higher during initial choice behavioral than continuous choice behavior. It indicated that stronger mPFC-NAc functional connections are required during controlled information processing (dominant in initial choice behavioral), rather than automatic information processing (dominant in continuous choice behavior). Coherence of mPFC-NAc activity is higher in WIS group than SHR group when choosing large/immediate rewards. It indicated that the decision impulsivity deficits in SHR rats results from mPFC-NAc weak functional connections. (5) Coherence of mPFC-NAc activity is higher in shift trials than continuous trials. Plus, WIS group showed an overall higher coherence than SHR group. This indicated that mPFC-NAc circuit heavily involves in controlled information processing, and SHR group has deficiency of this process. (6) Regression analysis showed that coherence difference of mPFC-NAc activity in prediction period has positive correlation with delayed large reward selection rate in WIS group, that is, the more coherence of mPFC-NAc Theta activity increased during prediction period, the less decision impulsivity WIS rats behaved during choice period. However, the coherence difference cannot predict decision impulsivity in SHR group.

Conclusion: mPFC-NAc heavily involves in decision impulsivity. Increase of coherence of mPFC-NAc theta oscillation in prediction period can predict impulsivity level. The study revealed that weak mPFC-NAc functional connections mediate decision impulsivity in ADHD and brought new perspectives in the treatment of ADHD.

Key words: attention deficit/hyperactivity disorder, decision impulsivity, mPFC, NAc, neural network oscillation