ISSN 1671-3710
CN 11-4766/R

›› 2010, Vol. 18 ›› Issue (9): 1440-1448.

Previous Articles     Next Articles

Effect of Genetic Polymorphisms on Neural Circuits of Emotion Regulation

CHEN Tao-Lin;LUO Yue-Jia   

  1. State Key Laboratory of Cognitive Neurosciences and Learning, Beijing Normal University, Beijing 100875, China
  • Received:2009-07-02 Revised:1900-01-01 Online:2010-09-15 Published:2010-09-15
  • Contact: LUO Yue-Jia

Abstract: As multiple utilization of the brain imaging and genetic analysis, it has greatly advanced the discoveries on neurobiology of emotional regulation in recent ten years. The growing converging evidences showed neural circuits of emotion regulation primarily involved in the connection and interaction of dorsal-ventral prefrontal circuits, prefrontal-amygdala circuits and cortical-limbic circuits, which might be affected by variant of genes such as 5-hydroxytryptamine transporter (5-HTT), Catechol-O- methyltransferase (COMT), tryptophan hydroxylase 2 (TPH2), and the interaction of different genes aslo had important effect on the neural circuits of emotion regulation.

Key words: emotional regulation, affective disorder, neural circuits, genetic polymorphisms, imaging genetics