Abstract:

Inhibitory control, which refers to the ability to successfully suppress dominant behavior and irrelevant stimuli, is an important mechanism in the cognitive function. Neuroimaging studies suggested that the age-related declines in inhibitory control associated with the cortical shrinkage and loss of neurons in the prefrontal cortex. What’s more, age-related increases in PFC activation to functional compensation have been found in functional neuroimaging studies. Meanwhile, genetics studies show that cognitive aging was marked by heterogeneity. The effect of common genetic variants contributed to the observed increase in heterogeneity in normal aging. Imaging genetics, which combines imaging and genetics advantages, should be used to explore the inhibitory control and aging under the framework of Genes-Brain-Behavior.

Key words: inhibitory control, aging, prefrontal cortex, genetic, Imaging genetics