Abstract: Although the working memory modal by Baddeley is supported by various experimental results, the relationship between working memory and long-term memory is unsolved. The evidence from neuropsychology showed that prefrontal region was involved in both working memory and episodic memory tasks. Meanwhile, some researches found that there was different prefrontal sub-regions which execute separate functions for working memory and episodic memory. The study topic in future should be focus on the interaction between the two memory systems. The precious studies results show the age effect and material-specific on the temporal and scalp distribution when the studied experience stored at episodic memory impact the content of working memory. On the other hand, the earlier process stage of working memory may determine successful episodic memory forming. The future studies should focus on exploring the neuropsychological mechanism of two memory system by employing various approaches supported by theoretical frame

Key words: working memory, episodic memory, prefrontal region, age effect, material-specific