Abstract: Neurogranin (RC3 )is a brain-specific protein newly found，which is a neuron-specific，Ca2＋sensitive/calmodulin-binding protein kinase C substrate, and is involved in the process of signaling conduction and long-term potentiation. It is mainly distributed in the hippocampus and forebrain. Furthermore, it has been mostly found in dendritic spines and neuronal cell bodies of these areas, with some infrequent presence in axonal profiles and in the internal capsule. During the different phase of brain development, the numbers and distribution of neurogranin will be happened to change. Recently the studies on neurogranin began to focus on examining the relationship between it and aging, diseases and stress, and to discuss the functional pathway and the possible brain mechanism involving in aging, disease and stress. This review attempts to introduce the related researches, which may shed new light on the understanding of the relationship between brain and behavior as well as the mechanism studies.

Key words: Neurogranin, aging, disease, stress