心理科学进展 ›› 2023, Vol. 31 ›› Issue (4): 631-640.doi: 10.3724/SP.J.1042.2023.00631
收稿日期:
2021-05-20
出版日期:
2023-04-15
发布日期:
2022-12-30
通讯作者:
雷怡
E-mail:leiyi821@vip.sina.com
基金资助:
ZHANG Jie1, ZHANG Huoyin2, LI Hong1, LEI Yi1()
Received:
2021-05-20
Online:
2023-04-15
Published:
2022-12-30
Contact:
LEI Yi
E-mail:leiyi821@vip.sina.com
摘要:
睡眠问题可能会诱发恐惧相关情绪障碍(焦虑、创伤性应激障碍、恐怖症等), 研究睡眠影响恐惧学习的认知神经机制, 有助于增强对恐惧相关情绪障碍的预测、诊断和治疗。以往研究表明睡眠剥夺影响恐惧习得和消退主要是通过抑制vmPFC活动, 阻碍其与杏仁核的功能连接, 从而导致恐惧习得增强或是消退学习受损。进一步研究发现睡眠不同阶段对恐惧学习相关脑区有独特的影响: 剥夺(缺乏)快速眼动睡眠会抑制vmPFC活动、增强杏仁核、海马激活, 导致恐惧习得增强, 消退学习受损, 此外边缘皮层的功能连接减少破坏了记忆巩固(恐惧记忆和消退记忆); 而慢波睡眠主要与海马变化有关, 慢波睡眠期间进行目标记忆重激活可促进恐惧消退学习。未来研究需要增加睡眠影响恐惧泛化的神经机制研究、及昼夜节律中断对恐惧消退的影响, 以及关注动物睡眠研究向人类睡眠研究转化中存在的问题。
中图分类号:
张婕, 张火垠, 李红, 雷怡. (2023). 睡眠对恐惧学习的影响及其认知神经机制. 心理科学进展 , 31(4), 631-640.
ZHANG Jie, ZHANG Huoyin, LI Hong, LEI Yi. (2023). The effect of sleep on fear learning and its cognitive neural mechanisms. Advances in Psychological Science, 31(4), 631-640.
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