ISSN 1671-3710
CN 11-4766/R

心理科学进展 ›› 2015, Vol. 23 ›› Issue (9): 1579-1587.doi: 10.3724/SP.J.1042.2015.01579

• 研究前沿 • 上一篇    下一篇



  1. (西南大学心理学部, 重庆 400715)
  • 出版日期:2015-09-15 发布日期:2015-09-15
  • 通讯作者: 郑涌, E-mail:

Neural Mechanisms Underlying the Impact of Sleep Deprivation on Fear Processing

FENG Pan; ZHENG Yong   

  1. (Faculty of Psychological Science, Southwest University, Chongqing 400715, China)
  • Online:2015-09-15 Published:2015-09-15
  • Contact: ZHENG Yong, E-mail:


睡眠剥夺与恐惧情绪加工的各个过程息息相关。睡眠剥夺损害了恐惧的习得过程, 而且影响着杏仁核、内侧前额叶的活动及它们之间的功能连接; 睡眠剥夺削弱了恐惧记忆的巩固和再巩固过程, 不仅破坏了恐惧记忆再巩固过程相关蛋白质和酶的合成, 同时也影响着海马、杏仁核、内侧前额叶的活动以及它们之间的功能连接; 睡眠剥夺损害了恐惧的消退, 同时也改变了海马、杏仁核等相关脑区的活动模式。未来的研究应从睡眠剥夺影响恐惧情绪加工的认知神经机制、睡眠剥夺与恐惧情绪相关障碍的关系等角度展开, 力图深入理解睡眠剥夺影响恐惧情绪加工的认知神经机制。

关键词: 恐惧, 睡眠剥夺, 杏仁核, 内侧前额叶


Processing of a fear memory can be divided into four distinct phases: acquisition, consolidation, reconsolidation, and extinction. Sleep deprivation has been shown to impair the process of fear acquisition as it affects activity of the amygdala and medial prefrontal cortex, as well as the functional connectivity between them. Sleep deprivation also weakens fear memory consolidation by interfering with activities of the hippocampus, amygdala, and prefrontal cortex, as well as the functional connectivity among them. In addition, sleep deprivation can attenuate fear memory reconsolidation, not only by impairing the synthesis of proteins and enzymes closely related to memory consolidation, but also by affecting activity in the amygdala and ventromedial prefrontal cortex. Finally, sleep deprivation can impair extinction of a fear memory as it can alter activity patterns of the hippocampus and amygdala. Future studies should focus on the cognitive neural mechanisms underlying the impact of sleep deprivation on processing of a fear memory as well as the relationship between sleep deprivation and fear-related disorders.