ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2016, Vol. 24 ›› Issue (6): 923-933.doi: 10.3724/SP.J.1042.2016.00923

• 研究前沿 • 上一篇    下一篇

调控去甲肾上腺素能系统对防治创伤后应激障碍的影响

王红波; 朱湘茹   

  1. (河南大学认知与行为研究所, 开封 475001)
  • 收稿日期:2015-07-26 出版日期:2016-06-15 发布日期:2016-06-15
  • 通讯作者: Email: zhuxiangru@gmail.com
  • 基金资助:

    国家自然科学基金青年项目“自我启动影响奖赏加工的ERP研究”(31300846)。

Effect of noradrenergic regulation on prevention and treatment of posttraumatic stress disorder

WANG Hongbo; ZHU Xiangru   

  1. (Institute of Cognition and Behavior, Henan University, Kaifeng 475001, China)
  • Received:2015-07-26 Online:2016-06-15 Published:2016-06-15
  • Contact: Email: zhuxiangru@gmail.com

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1929

被引次数

1

摘要：

个体经历严重创伤性事件后可能会形成创伤后应激障碍(posttraumatic stress disorder, PTSD)。在创伤经历中形成的情绪记忆是以后发展为PTSD的重要病理机制。PTSD的形成涉及到情绪记忆的过度巩固, 而去甲肾上腺素能神经信号可增强情绪记忆的巩固和再巩固。因此, 在创伤记忆的巩固和再巩固期间阻断去甲肾上腺素能神经信号, 而在创伤记忆的消退期间增强去甲肾上腺素能神经信号, 可能会破坏和或抑制病理性的情绪记忆, 从而预防或治疗PTSD。

关键词: 去甲肾上腺能, 巩固, 消退, 再巩固, 创伤后应激障碍

Abstract:

Exposure to traumatic experience may result in the development of posttraumatic stress disorder (PTSD). The formation of emotional memories following exposure to a traumatic event is an important mechanism for the subsequent development of PTSD. Animal and human research suggests that the development of PTSD may involve the overconsolidation of memories of a traumatic experience. Noradrenergic signaling strengthens the consolidation and reconsolidation of emotional memory. Therefore, the enhancement of noradrenergic signaling during extinction may strengthen the consolidation of extinction memory, whereas the disruption of noradrenergic signaling during consolidation and reconsolidation may abolish the pathological emotional component of memories, thus alleviating PTSD.

Key words: noradrenergic, consolidation, extinction, reconsolidation, posttraumatic stress disorder