ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2015, Vol. 23 ›› Issue (8): 1409-1417.doi: 10.3724/SP.J.1042.2015.01409

• 研究前沿 • 上一篇    下一篇

感知觉-运动系统在药物相关线索反应中的作用及神经机制

曾红1;姜醒2;叶浩生1   

  1. (1广州大学心理与脑科学研究中心, 广州大学心理学系, 广州 510006)
    (2    暨南大学医学院预防医学系, 广州 510632)
  • 收稿日期:2014-08-26 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 叶浩生, E-mail: yehaosheng0817@163.com
  • 基金资助:

    国家自然科学基金项目(31271113), 广东省“创新强校工程”省级重大项目(2014WZDXMOZ)。

The Function and Mechanism of Sensorimotor System in the #br# Process of Drug Cue-related Reactivity

ZENG Hong1; JIANG Xing2; YE HaoShen1   

  1. (1 The Research Center of Psychology and Brain Science, Department of Psychology, Guangzhou University, Guangzhou 510006, China) (2 Department of Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China)
  • Received:2014-08-26 Online:2015-08-15 Published:2015-08-15
  • Contact: YE HaoShen, E-mail: yehaosheng0817@163.com

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摘要：

药物相关线索反应是成瘾行为的重要标志, 它直接导致心理渴求和强迫性的刺激-反应式自动化用药行为。其神经机制是包含了经典和操作条件反射的联结学习。在联结过程中, 除奖赏系统外, 感觉-动作系统在相关线索反应中也起到了重要作用。其机理可能是与感觉运动脑区部分重合的镜像神经的理解、分析和推测动作意图目的以及内隐模仿的功能有关。另外, 动作记忆的形成及功能也可能在这种自动化动作图式的形成中起到了重要的作用。其确切的机制需要进一步研究证据。

关键词: 成瘾行为, 相关线索反应, 自动化动作, 镜像神经, 动作记忆

Abstract:

Drug cue-related reactivity is an important mark of drug addiction. It results in stimulus-response craving and compulsive drug use. The neurobiological mechanism of this compulsive behavior is the stimula-automatized action schemata, which is the result of association learning, including classic and operant conditioned reflex. Recent research indicates that the function of the mirror neuro system which overlaps part of the sensory-motor brain regions and have been known to help with understanding actions, analysis, inferring intentions and goals of the actions, inner imitating, may facilitate the formation of automatized action schemata and result in repeated drug use and relapse. In addition, there is evidence that the action memory’s mechanism and function play an important role in the processing of automatic action.

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