ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2023, Vol. 31 ›› Issue (suppl.): 133-133.

• 视觉功能障碍与康复 • 上一篇    下一篇

Effects of altered-reality training on interocular disinhibition in amblyopia

Xinxin Dua,b, Lijuan Liuc, Xue Donga,b, Min Baoa,b,d   

  1. aCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China, 100101;
    bDepartment of Psychology, University of Chinese Academy of Sciences, Beijing, China, 100101;
    cBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Captital Medical University, Beijing, China, 100730;
    dState Key Laboratory of Brain and Cognitive Science, Beijing, China, 100101
  • 出版日期:2023-08-26 发布日期:2023-09-08

Effects of altered-reality training on interocular disinhibition in amblyopia

Xinxin Dua,b, Lijuan Liuc, Xue Donga,b, Min Baoa,b,d   

  1. aCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China, 100101;
    bDepartment of Psychology, University of Chinese Academy of Sciences, Beijing, China, 100101;
    cBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Captital Medical University, Beijing, China, 100730;
    dState Key Laboratory of Brain and Cognitive Science, Beijing, China, 100101
  • Online:2023-08-26 Published:2023-09-08

Abstract: PURPOSE: Training of viewing an altered-reality environment dichoptically has been found to reactivate human adult ocular dominance plasticity, allowing improvement of vision for amblyopia. One suspected mechanism for this training effect is ocular dominance rebalancing through interocular disinhibition. Here, we investigated whether the training modulated the neural responses reflecting interocular inhibition.
METHODS: Thirteen patients with amblyopia and 11 healthy controls participated in this study. Before and after six daily altered-reality training sessions, participants watched flickering video stimuli with their steady-state visually evoked potential (SSVEP) signals recorded simultaneously. We assessed the amplitude of SSVEP response at intermodulation frequencies, which was a potential neural indicator of interocular suppression.
RESULTS: Training weakened the intermodulation response only in the amblyopic group, which was in agreement with the hypothesis that the training reduced interocular suppression specific to amblyopia. Moreover, even one month after the training ended, we could still observe this neural training effect.
CONCLUSIONS: These findings provide preliminary neural evidence in support of the disinhibition account for treating amblyopia. The results can be explained with the ocular opponency model.

Key words: amblyopia, altered-reality training, interocular disinhibition, steady-state visually evoked potential, intermodulation responses