ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2017, Vol. 25 ›› Issue (3): 393-403.doi: 10.3724/SP.J.1042.2017.00393

• 研究构想 • 上一篇    下一篇

拖延的认知神经机制与基因：行为−脑−基因的多角度研究

张顺民; 冯廷勇   

  1. (西南大学心理学与社会发展研究中心, 心理学部, 重庆 400715)
  • 收稿日期:2016-06-10 出版日期:2017-03-15 发布日期:2017-03-15
  • 通讯作者: 冯廷勇, E-mail: fengty0@swu.edu.cn
  • 基金资助:

    国家自然科学基金面上项目(31271117; 31571128)、重庆市人文社会科学重点研究基地重点项目(16SKB007)、中央高校基本科研业务经费创新团队项目(SWU1509392)资助。

Neural mechanisms and gene of procrastination based on a behavior-brain-gene perspective

ZHANG Shunmin; FENG Tinyong   

  1. (Research Center of Psychology and Social Development, Faculty of Psychology, Southwest University, Chongqing 400715, China)
  • Received:2016-06-10 Online:2017-03-15 Published:2017-03-15
  • Contact: FENG Tinyong, E-mail: fengty0@swu.edu.cn

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摘要：

拖延是一种普遍存在, 具有跨时间和跨情景稳定性的问题行为, 严重的拖延甚至会危害到人们的工作、学习及身心健康。鉴于目前对于拖延的认知神经机制仍不清楚, 研究模态较为单一, 本研究拟从行为−脑−基因的系统研究思路出发, 以多模态MRI (Task、Resting、VBM和DTI)为主要技术手段, 将HTR2B基因多态性作为突破口, 系统考察拖延的认知机制、神经基础和遗传基础, 并试图制定拖延的应对与干预方案。研究分为4个部分：(1)从行为上, 结合预期恐惧范式和跨期选择范式探索其拖延决策的机制; (2)在神经层面上, 采用MRI多模态技术系统考察拖延行为的神经基础; (3)在基因层面上, 采用分子遗传学方法, 将HTR2B设定为靶基因以深入研究拖延的遗传基础, 并考察脑结构和脑功能在基因与行为间的中介作用; (4)最后从行为干预与脑的可塑性的角度, 设计拖延的干预方法来改善拖延行为并验证拖延的神经机制。

关键词: 拖延行为, 多模态技术, HTR2B基因, 跨期选择

Abstract:

Established as a widespread problematic behavioral and a stable individual tendency across time and different contexts, procrastination is harmful to the procrastinator’s psychological, physical, and financial well-being. Given the cognitive mechanism of procrastination is unclear and methodologies in previous studies was dated, we are developing studies from a behavior-brain-gene perspective, using a multi-modal MRI (Task, Resting, VBM and DTI) methodology and considering HTR2B gene as a breakthrough direction, to reveal the cognitive mechanisms, neural mechanisms and hereditary basis of procrastination systematically. In addition, we intended to design interventions for procrastination as well. Our studies will includes four aspect: (1) from a behavioral perspective, we are exploring the cognitive mechanism of deciding to procrastinate by combining paradigm of dread studies with intertemporal choice task; (2) from a neural perspective, we are using a multi-modal MRI methodoloty to reveal the neural mechanism of procrastination; (3) from a genetic perspective, we are utilizing molecular genetic methods and taking the HTR2B gene as our targeted gene to disclose the genetic mechanism of procrastination and test a mediating role of neural structure or function between hereditary basis and procrastination; (4) Considering intervention for procrastination and malleability of brain, we also intend to design training program to reduce procrastination and test procrastination related neural plasticity.

Key words: procrastination, prospective emotion, multi-modal MRI, HTR2B gene, intertemporal choice