ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2014, Vol. 22 ›› Issue (4): 677-684.doi: 10.3724/SP.J.1042.2014.00677

• 研究前沿 • 上一篇    下一篇

反社会行为潜在遗传因素的全基因组关联分析

胡文菊;郑红丽   

  1. 中国政法大学社会学院, 北京 100088
  • 收稿日期:2013-07-17 出版日期:2014-04-15 发布日期:2014-04-15
  • 通讯作者: 郑红丽

Urevaling the Underlying Genetic Factor of Antisocial Behavior Using Genome-Wide Association Study Methodology

HU Wenju;ZHENG Hongli   

  1. School of sociology, China University of Political Science and Law, Beijing 100088, China
  • Received:2013-07-17 Online:2014-04-15 Published:2014-04-15
  • Contact: ZHENG Hongli

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2131

被引次数

1

摘要：

反社会行为是一种受基因和环境共同影响的复杂性行为, 但单个基因如单胺氧化酶基因(MAOA)、5-羟色胺转运体启动因子基因(5-HTT)、儿茶酚-o-甲基转移酶(COMT)基因的影响并不能全面解释其产生的分子遗传机制。来自分子遗传学研究取向的方法—— 全基因组关联分析(genome-wide association study, GWAS), 把人类基因组中数以百万计的单核苷酸(SNPs)和复制数变异(CNVs)作为遗传标记, 在全基因组层面上, 开展多中心、大样本的关联研究, 经过反复验证来发现与外在表型相关的基因位点, 为进一步了解反社会行为复杂分子遗传机制提供了重要的线索。未来的研究应该通过科学的实验设计将精确的基因分型技术与心理、环境因素相结合, 实现对复杂性行为或特质的基因-心理-环境模型的成因性分析。

关键词: 反社会行为, 分子遗传机制, 全基因组关联分析

Abstract:

Although antisocial behavior is a complex condition with environmental and genetic etiologies, the single susceptibility gene such as the Monoamine oxidase A (MAOA) gene, the serotonin transporter promoter gene (5-HTT) and the catechol O-methyltransferase gene, can’t completely interpret the molecular genetics mechanism of the antisocial behavior. The genome-wide association study (GWAS) methodology from molecular genetics views millions of large number of single nucleotide polymorphisms (SNPs) and copy number variation (CNVs) as genetic markers to search the genetic locus related to external phenotype on the level of entire genome by high-throughput genotyping technology and so it can provide important clues for the further understanding of hereditary factors of antisocial behavior.In order to achieve the analysis for the gene-psychology-environment mechanism of complex traits or behavior, future studies should combine the accurate genotyping techniques with mental and environment factors.

Key words: antisocial behavior, molecular genetics mechanism, genome-wide association study