ISSN 0439-755X
CN 11-1911/B

Acta Psychologica Sinica ›› 2022, Vol. 54 ›› Issue (6): 604-612.doi: 10.3724/SP.J.1041.2022.00604

• Reports of Empirical Studies • Previous Articles     Next Articles

Sustained hyperarousal induced by acute stress in tryptophan-hydroxylase-2 genetic deficient male mice

ZHOU Ping1, XIAO Hua1, LI Yonghui2,3, DONG Xinwen2()   

  1. 1Department of Psychology, Educational Science Faculty, Hunan Normal University, Changsha, Hunan 410081, China
    2CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
    3Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2021-08-17 Online:2022-04-26
  • Contact: DONG Xinwen
  • Supported by:
    research start-up fund of Institute of Psychology, Chinese Academy of Sciences(E0CX4810)


Severe stress stimulation will cause persistent hyperarousal state, which is the core symptom of various stress disorders and promotes the occurrence and development of other symptoms. This study focused on the role of 5-hydroxytryptamine in the occurrence and development of stress-induced hyperarousal. By measuring the auditory startle reflex level to reflect the state of hyperarousal, we investigated the changes of hyperarousal in tryptophan hydroxylase-2 gene deficient mice before and after predator exposure or electric footshock stress. Studies have found that male genetically deficient mice showed hyperarousal performance lasting for more than one week after stress, while wild-type mice showed a hyperarousal state that recovered quickly. The results suggest that the decrease of serotonin caused by gene deficiency may be a susceptible factor of persistent hyperarousal induced by severe stress.

Key words: hyperarousal, 5-hydroxytryptamine, tryptophan-hydroxylase-2, auditory startle reflex