ISSN 1671-3710
CN 11-4766/R
主办：中国科学院心理研究所
出版：科学出版社

心理科学进展 ›› 2010, Vol. 18 ›› Issue (9): 1440-1448.

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基因多态性对情绪调节神经回路的影响

陈桃林;罗跃嘉   

  1. 北京师范大学认知神经科学与学习国家重点实验室, 北京 100875
  • 收稿日期:2009-07-02 修回日期:1900-01-01 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 罗跃嘉

Effect of Genetic Polymorphisms on Neural Circuits of Emotion Regulation

CHEN Tao-Lin;LUO Yue-Jia   

  1. State Key Laboratory of Cognitive Neurosciences and Learning, Beijing Normal University, Beijing 100875, China
  • Received:2009-07-02 Revised:1900-01-01 Online:2010-09-15 Published:2010-09-15
  • Contact: LUO Yue-Jia

PDF (PC)

2165

被引次数

38

摘要： 随着脑成像和基因分析等新技术手段的综合运用, 情绪调节的神经生物学基础研究有了很大进展。综述相关研究表明: 情绪调节的神经回路涉及背侧-腹侧前额叶、前额叶-杏仁核和皮层-边缘系统的相互作用, 这些神经回路受到5-羟色胺传运体(5-hydroxytryptamine transporter, 5-HTT)、儿茶酚转甲酶 (Catechol-O-methyltransferase, COMT)和色氨酸羟化酶2(Tryptophan hydroxylase 2, TPH2)等基因变异, 以及不同基因多态之间交互作用的影响。情绪调节神经回路的功能出现障碍将导致情绪疾病的产生。

关键词: 情绪调节, 情绪障碍, 神经回路, 基因多态性, 基因影像学

Abstract: As multiple utilization of the brain imaging and genetic analysis, it has greatly advanced the discoveries on neurobiology of emotional regulation in recent ten years. The growing converging evidences showed neural circuits of emotion regulation primarily involved in the connection and interaction of dorsal-ventral prefrontal circuits, prefrontal-amygdala circuits and cortical-limbic circuits, which might be affected by variant of genes such as 5-hydroxytryptamine transporter (5-HTT), Catechol-O- methyltransferase (COMT), tryptophan hydroxylase 2 (TPH2), and the interaction of different genes aslo had important effect on the neural circuits of emotion regulation.

Key words: emotional regulation, affective disorder, neural circuits, genetic polymorphisms, imaging genetics